21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

2015 ◽  
Vol 26 (9) ◽  
pp. 1626-1632 ◽  
Author(s):  
Christopher L. Hendrickson ◽  
John P. Quinn ◽  
Nathan K. Kaiser ◽  
Donald F. Smith ◽  
Greg T. Blakney ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Mass Analysis ◽  
Ultrahigh Resolution ◽  
Ion Cyclotron ◽  
Resolution Mass ◽  
National Resource

scholarly journals Identification of Human Serum Peptides in Fourier Transform Ion Cyclotron Resonance Precision Profiles

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Simone Nicolardi ◽  
Hans Dalebout ◽  
Marco R. Bladergroen ◽  
Wilma E. Mesker ◽  
Rob A. E. M. Tollenaar ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Human Serum ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Biomarker Discovery ◽  
High Mass ◽  
Ion Cyclotron Resonance ◽  
Ultrahigh Resolution ◽  
Peptide Profile ◽  
Ion Cyclotron

The continuous efforts to find new prognostic or diagnostic biomarkers have stimulated the use of mass spectrometry (MS) profiles in a clinical setting. In the early days (about one decade ago), a single low-resolution mass spectrum derived from an individual’s body fluid was used for comparative studies. However, a peptide profile of a complex mixture is most informative when recorded on an ultrahigh resolution instrument such as a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. In this study we show the benefits of the ultrahigh resolving power and the high mass accuracy and precision provided by an FTICR mass spectrometer equipped with a 15-tesla magnet. The ultrahigh-resolution data not only allow assignment of fragment ions with high charge states (4+, 5+) but also enhance confidence of human serum peptide identifications from tandem MS experiments. This is exemplified with collision-induced dissociation (CID) and electron transfer dissociation (ETD) data of middle-down-sized endogenous or protein-breakdown peptides that are of interest in biomarker discovery studies.

Ultrahigh‐resolution Fourier transform ion cyclotron resonance mass spectrometer

1993 ◽  
Vol 64 (7) ◽  
pp. 1845-1852 ◽  
Author(s):  
George M. Alber ◽  
Alan G. Marshall ◽  
Nicholas C. Hill ◽  
Lutz Schweikhard ◽  
Tom L. Ricca
Keyword(s):  
Fourier Transform ◽  
Mass Spectrometer ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Ultrahigh Resolution ◽  
Ion Cyclotron
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