Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

1995 ◽  
Vol 38 (13) ◽  
pp. 2449-2462 ◽  
Author(s):  
Paul E. Finke ◽  
Shrenik K. Shah ◽  
Daniel S. Fletcher ◽  
Bonnie M. Ashe ◽  
Karen A. Brause ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Stereospecific Synthesis ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

1993 ◽  
Vol 36 (6) ◽  
pp. 771-777 ◽  
Author(s):  
William K. Hagmann ◽  
Amy L. Kissinger ◽  
Shrenik K. Shah ◽  
Paul E. Finke ◽  
Conrad P. Dorn ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase ◽  
Orally Active

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

1992 ◽  
Vol 35 (21) ◽  
pp. 3745-3754 ◽  
Author(s):  
Shrenik K. Shah ◽  
Conrad P. Dorn ◽  
Paul E. Finke ◽  
Jeffrey J. Hale ◽  
William K. Hagmann ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Elastase 1 ◽  
Human Leukocyte Elastase ◽  
Orally Active

Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase

Biochemistry ◽  
1992 ◽  
Vol 31 (35) ◽  
pp. 8160-8170 ◽  
Author(s):  
W. B. Knight ◽  
B. G. Green ◽  
R. M. Chabin ◽  
P. Gale ◽  
A. L. Maycock ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Mechanism of Inhibition of Human Leukocyte Elastase by .beta.-Lactams. 2. Stability, Reactivation Kinetics, and Products of .beta.-Lactam-Derived E-I Complexes

Biochemistry ◽  
1995 ◽  
Vol 34 (44) ◽  
pp. 14331-14343 ◽  
Author(s):  
B. G. Green ◽  
R. Chabin ◽  
S. Mills ◽  
D. J. Underwood ◽  
S. K. Shah ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Beta Lactam ◽  
Beta Lactams ◽  
Leukocyte Elastase ◽  
Mechanism Of Inhibition ◽  
Human Leukocyte Elastase

Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study

1995 ◽  
Vol 3 (2) ◽  
pp. 125-128 ◽  
Author(s):  
William C. Groutas ◽  
Radhika Venkataraman ◽  
Lee S. Chong ◽  
James E. Yoder ◽  
Jeffrey B. Epp ◽  
...  
Keyword(s):  
Proteolytic Enzymes ◽  
Human Leukocyte ◽  
Cathepsin G ◽  
Activity Relationship ◽  
Proteinase 3 ◽  
Leukocyte Elastase ◽  
Structure Activity ◽  
Human Leukocyte Elastase ◽  
Relationship Study ◽  
Potential Inhibitors

ChemInform Abstract: Inhibition of Human Leukocyte Elastase by Functionalized N-Aryl-3,3- dihalogenoazetidin-2-ones. Stereospecific Synthesis and Chiral Recognition of Dissymmetrically C3-Substituted β-Lactams.

ChemInform ◽  
2010 ◽  
Vol 28 (30) ◽  
pp. no-no
Author(s):  
C. DOUCET ◽  
I. VERGELY ◽  
M. REBOUD-RAVAUX ◽  
J. GUILHEM ◽  
R. KOBAITER ◽  
...  
Keyword(s):  
Chiral Recognition ◽  
Human Leukocyte ◽  
Stereospecific Synthesis ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Electrospray ionization mass spectrometry as a mechanistic tool: Mass of human leukocyte elastase and a .beta.-lactam-derived E-I complex

Biochemistry ◽  
1993 ◽  
Vol 32 (8) ◽  
pp. 2031-2035 ◽  
Author(s):  
W. B. Knight ◽  
K. M. Swiderek ◽  
T. Sakuma ◽  
J. Calaycay ◽  
J. E. Shively ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Human Leukocyte ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Beta Lactam ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase

Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase

1994 ◽  
Vol 37 (9) ◽  
pp. 1259-1261 ◽  
Author(s):  
Frederick J. Brown ◽  
Donald W. Andisik ◽  
Peter R. Bernstein ◽  
Craig B. Bryant ◽  
Chris Ceccarelli ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Leukocyte Elastase ◽  
Human Leukocyte Elastase ◽  
Peptidic Inhibitors ◽  
Orally Active
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