New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids

1990 ◽  
Vol 33 (2) ◽  
pp. 849-854 ◽  
Author(s):  
Susan E. Hagen ◽  
John M. Domagala ◽  
Carl L. Heifetz ◽  
Joseph P. Sanchez ◽  
Marjorie Solomon
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids ◽  
Antibacterial Agents

Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids

2012 ◽  
Vol 67 (3-4) ◽  
pp. 123-128
Author(s):  
Anna Pachuta-Stec ◽  
Urszula Kosikowska ◽  
Anna Chodkowska ◽  
Monika Pitucha ◽  
Anna Malm ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Condensation Reaction ◽  
Primary Amines ◽  
Pharmacological Activities

N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities

ChemInform Abstract: Studies on Antibacterial Agents. Part 1. Synthesis of Substitued 6,7-Dihydro-1-oxo-1H,5H-benzo(i,j)quinolizine-2-carboxylic Acids.

ChemInform ◽  
1990 ◽  
Vol 21 (16) ◽  
Author(s):  
H. ISHIKAWA ◽  
F. TABUSA ◽  
H. MIYAMOTO ◽  
M. KANO ◽  
H. UEDA ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Antibacterial Agents

scholarly journals Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
C. Zamperini ◽  
G. Maccari ◽  
D. Deodato ◽  
C. Pasero ◽  
I. D’Agostino ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antibacterial Agents

scholarly journals Pyridonecarboxylic acids as antibacterial agents. V. Synthesis of 1-vinyl-1,4-dihydro-4-oxo-1,8- and 1,6-naphthyridine-3-carboxylic acids.

1985 ◽  
Vol 33 (10) ◽  
pp. 4402-4408 ◽  
Author(s):  
SHINSAKU MISHIO ◽  
TOHRU HIROSE ◽  
AKIRA MINAMIDA ◽  
JUNICHI MATSUMOTO ◽  
SHINSAKU MINAMI
Keyword(s):  
Carboxylic Acids ◽  
Antibacterial Agents

ChemInform Abstract: Synthesis and Biological Activity of 5-Alkyl-1,7,8-trisubstituted-6- fluoroquinoline-3-carboxylic Acids.

ChemInform ◽  
2010 ◽  
Vol 22 (27) ◽  
pp. no-no
Author(s):  
S. E. HAGEN ◽  
J. M. DOMAGALA ◽  
C. L. HEIFETZ ◽  
J. JOHNSON
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids

Synthesis and Biological Activity of Arylcyclopentane-1-carboxylic Acids Aminoesters

2019 ◽  
Vol 89 (5) ◽  
pp. 1051-1054
Author(s):  
A. A. Aghekyan ◽  
G. G. Mkryan ◽  
A. S. Tsatinyan ◽  
G. V. Gasparyan
Keyword(s):  
Biological Activity ◽  
Carboxylic Acids

scholarly journals Regioselective Synthesis of Novel [N-(4-Oxo-3-(2-phenyl-1,8-naphthyridin-3-yl)-thiazolidin-2-ylidene)]acetamide/benzamides and their Biological Activity

2019 ◽  
Vol 31 (6) ◽  
pp. 1246-1250
Author(s):  
RAMALINGAM KUNDENAPALLY ◽  
RAMESH DOMALA ◽  
B. SREENIVASULU
Keyword(s):  
Biological Activity ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Regioselective Synthesis ◽  
Chloroacetyl Chloride ◽  
Bacterial Strains ◽  
Physical Data

In an attempt to discover the new antibacterial agents to fight the bacterial infections, a series of 1,8-naphthyridine based 2-iminothiazolidin-4-one derivatives was synthesized by a straight-forward regioselective synthesis. 2-Phenyl-1,8-naphthyridin-3-amine (2) was reacted with acetyl or aroyl isothiocyantes to give the corresponding N-[(2-phenyl-1,8-naphthyridin-3-yl)carbamothioyl)]acetamide or benzamides (3a-e). Finally, the target compounds [N-(4-oxo-3-(2-phenyl-1,8-naphthyridin-3-yl)thiazolidin-2-ylidene)]acetamide or benzamides (4a-e) were obtained by the reaction of thiourea (3a-e) with chloroacetyl chloride in presence of pyridine. All the synthesized products were formed in good yields and their structures were characterized by spectral (IR, EI-MS and NMR) and physical data. The biological activity of title compounds was evaluated against the bacterial strains and found to be more potent.

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