Thiourea derivatives of 2-aminooxazoles showing antibacterial and antifungal activity

1973 ◽  
Vol 16 (12) ◽  
pp. 1402-1405 ◽  
Author(s):  
George Crank ◽  
Martin Neville ◽  
Ray Ryden
Keyword(s):  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Thiourea Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

scholarly journals Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid

2008 ◽  
Vol 5 (4) ◽  
pp. 963-968 ◽  
Author(s):  
Sabir Hussain ◽  
Jyoti Sharma ◽  
Mohd Amir
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Activities ◽  
Hydroxybenzoic Acid ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Gram Negative ◽  
Thiadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity againstS. aureus(gram-positive) andE.coli(gram-negative) bacteria and antifungal activity againstA. nigerfungi using cup plate technique

scholarly journals Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest

2011 ◽  
Vol 8 (2) ◽  
pp. 748-752 ◽  
Author(s):  
Fawzia Zakaria El-Ablack
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetoacetate ◽  
Benzimidazole Derivative ◽  
Ethyl Cyanoacetate ◽  
The Other ◽  
Benzimidazole Derivatives ◽  
Chloroacetyl Chloride ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Reaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with acetyl acetone resulted in the formation of diazepine derivative (4). The reaction of 1 with ethyl cyanoacetate was studied to give 3-aminodiazepinone derivative (5). Also the reaction of 1 with acetophenone and/or benzophenone has been investigated to give the fused imidazolines 6 and 7 respectively, while the reaction of 1 with cyclopentanone gave benzimidazolyl derivative (8). Treatment of 1 with chloroacetyl chloride gave the fused pyrazinone (9). The treatment of 1 with benzoin gave the derivative (10). The structures of the hitherto unknown compounds have been confirmed from analytical and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activity.

scholarly journals Design and Synthesis of Some New Derivatives of Chlorobenzyl-Oxy-Phenyl-Ethyl-Thio-1H-Tetrazole and Study Their Antibacterial and Antifungal Activity

2021 ◽  
Author(s):  
Ajay N Ambhore
Keyword(s):  
Antifungal Activity ◽  
Carboxylic Acid ◽  
Spectral Characterization ◽  
Antibacterial And Antifungal Activity ◽  
Design And Synthesis ◽  
Structural Resemblance ◽  
Chemistry Research ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Tetrazole Derivatives

Abstract In recent years tetrazole scaffolds have been attracted interest in the field of synthetic and medicinal chemistry research. The unique structure of the tetrazole derivatives exhibits widespread applications in biology and technology. The close structural resemblance with carboxylic acid acts as a booster of the latter. Due to this diversified potential utilization, several methods are reported for the synthesis of tetrazole scaffolds. Here in this chapter, we describe the synthesis of chlorobenzyl-oxy-phenyl-ethyl-thio-1H-tetrazole derivatives ( 6a-p ). The newly synthesized derivatives are characterized by spectral characterization and screened for their antifungal activity. Among these, some of the newly synthesized compounds show potent antifungal activity.

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