scholarly journals Design and Synthesis of Some New Derivatives of Chlorobenzyl-Oxy-Phenyl-Ethyl-Thio-1H-Tetrazole and Study Their Antibacterial and Antifungal Activity

2021 ◽  
Author(s):  
Ajay N Ambhore
Keyword(s):  
Antifungal Activity ◽  
Carboxylic Acid ◽  
Spectral Characterization ◽  
Antibacterial And Antifungal Activity ◽  
Design And Synthesis ◽  
Structural Resemblance ◽  
Chemistry Research ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Tetrazole Derivatives

Abstract In recent years tetrazole scaffolds have been attracted interest in the field of synthetic and medicinal chemistry research. The unique structure of the tetrazole derivatives exhibits widespread applications in biology and technology. The close structural resemblance with carboxylic acid acts as a booster of the latter. Due to this diversified potential utilization, several methods are reported for the synthesis of tetrazole scaffolds. Here in this chapter, we describe the synthesis of chlorobenzyl-oxy-phenyl-ethyl-thio-1H-tetrazole derivatives ( 6a-p ). The newly synthesized derivatives are characterized by spectral characterization and screened for their antifungal activity. Among these, some of the newly synthesized compounds show potent antifungal activity.

Synthesis, Cytotoxicity by Bioluminescence Inhibition, Antibacterial and Antifungal Activity of ([1,2,4]Triazolo[1,5-c]quinazolin-2-ylthio)carboxylic Acid Amides

2009 ◽  
Vol 342 (11) ◽  
pp. 651-662 ◽  
Author(s):  
Lyudmila N. Antipenko ◽  
Alexander V. Karpenko ◽  
Sergey I. Kovalenko ◽  
Andrew M. Katsev ◽  
Elena Z. Komarovska-Porokhnyavets ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Carboxylic Acid ◽  
Antibacterial And Antifungal Activity ◽  
Carboxylic Acid Amides ◽  
Bioluminescence Inhibition ◽  
Antibacterial And Antifungal

scholarly journals Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid

2008 ◽  
Vol 5 (4) ◽  
pp. 963-968 ◽  
Author(s):  
Sabir Hussain ◽  
Jyoti Sharma ◽  
Mohd Amir
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Activities ◽  
Hydroxybenzoic Acid ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Gram Negative ◽  
Thiadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity againstS. aureus(gram-positive) andE.coli(gram-negative) bacteria and antifungal activity againstA. nigerfungi using cup plate technique

scholarly journals Synthesis, characterization and antimicrobial activity of novel tetrazoles clubbed with pyrimidine

2021 ◽  
Vol 9 (2) ◽  
pp. 116-122
Author(s):  
N.D. Bhoge ◽  
B.K. Magare ◽  
P. B. Mohite
Keyword(s):  
Aromatic Aldehydes ◽  
Oxidative Cyclization ◽  
Good Activity ◽  
Antibacterial And Antifungal Activity ◽  
E Coli ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Tetrazole Derivatives ◽  
Yield And Purity

An attempt was made to synthesize pyrimidine tetrazole derivatives of pharmaceutical interest by oxidative cyclization of chalcones with adequate yield and purity, prompted by the diversity of their wider usage and the fact that they are an integral part of genetic content. The present work involves the reaction of 5-(2,6-dimethylphenyl)-1H-tetrazole with acetic anhydride to yield 1-[5-(2,6-dimethylphenyl)-1H-tetrazol-1-yl] ethanone (1) and which then treated with different aromatic aldehydes in presence of alkaline medium to chalcones (2a-f). Reaction of chalcones (2a-f) with urea and thiourea to produce 5-[5-(2,6-dimethylphenyl)-1H-tetrazol-1-yl]-4-(substituted aryl ) pyrimidin-2-ol (3a-f) and 5-[5-(2,6-dimethylphenyl)-1H-tetrazol-1-yl]-4-(substituted aryl) pyrimidin-2-thiol (4a-f) respectively. All compounds were characterized by infrared spectroscopy (IR), H nuclear magnetic resonance (NMR), and mass spectrometry (MS) to prove the structure and assessed in vitro for their efficacy as antibacterial and antifungal activity against four bacteria. The compounds 3c, 3d and 3f and compounds 4c, 4d and 4f possess very good activity against and E. coli and the compounds 3e, 3c and 3a and compounds 4e,4b and 4c possess very good activity against fungi and .

scholarly journals Synthesis of Some New Benzimidazole Derivatives of Pharmaceutical Interest

2011 ◽  
Vol 8 (2) ◽  
pp. 748-752 ◽  
Author(s):  
Fawzia Zakaria El-Ablack
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetoacetate ◽  
Benzimidazole Derivative ◽  
Ethyl Cyanoacetate ◽  
The Other ◽  
Benzimidazole Derivatives ◽  
Chloroacetyl Chloride ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Reaction of 2-(aminomethyl)benzimidazole dihydrochloride (1) with ethyl acetoacetate was studied to give diazepinone-benzimidazole derivative (2), while, treatment of 1 with phenylhydrazono ethylacetoacetate afforded phenylhydrazino diazepinone derivative (3). On the other hand, reaction of 1 with acetyl acetone resulted in the formation of diazepine derivative (4). The reaction of 1 with ethyl cyanoacetate was studied to give 3-aminodiazepinone derivative (5). Also the reaction of 1 with acetophenone and/or benzophenone has been investigated to give the fused imidazolines 6 and 7 respectively, while the reaction of 1 with cyclopentanone gave benzimidazolyl derivative (8). Treatment of 1 with chloroacetyl chloride gave the fused pyrazinone (9). The treatment of 1 with benzoin gave the derivative (10). The structures of the hitherto unknown compounds have been confirmed from analytical and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activity.

Sign in / Sign up

Export Citation Format

Share Document