Ribose-Modified Nucleosides as Ligands for Adenosine Receptors:  Synthesis, Conformational Analysis, and Biological Evaluation of 1‘-C-Methyl Adenosine Analogues

2002 ◽  
Vol 45 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
Loredana Cappellacci ◽  
Grazia Barboni ◽  
Micaela Palmieri ◽  
Michela Pasqualini ◽  
Mario Grifantini ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Adenosine Receptors ◽  
Biological Evaluation ◽  
Modified Nucleosides ◽  
Adenosine Analogues

Synthesis, characterization, conformational analysis of a cyclic conjugated octreotate peptide and biological evaluation of 99mTc-HYNIC-His3-Octreotate as novel tracer for the imaging of somatostatin receptor-positive tumors

Amino Acids ◽  
2012 ◽  
Vol 44 (3) ◽  
pp. 933-946 ◽  
Author(s):  
Ashok Behera ◽  
Indranil Banerjee ◽  
Kakali De ◽  
Rudra Narayan Munda ◽  
Sankha Chattopadhayay ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Somatostatin Receptor ◽  
Biological Evaluation

Adenosine receptor-mediated calcium mobilization in cortical collecting tubule cells

1988 ◽  
Vol 255 (5) ◽  
pp. C581-C588 ◽  
Author(s):  
L. J. Arend ◽  
M. A. Burnatowska-Hledin ◽  
W. S. Spielman
Keyword(s):  
Intracellular Calcium ◽  
Pertussis Toxin ◽  
Adenosine Receptor ◽  
Adenosine Receptors ◽  
Free Calcium ◽  
Camp Production ◽  
Receptor System ◽  
Adenosine Analogues ◽  
Collecting Tubule ◽  
Cortical Collecting Tubule

To investigate the cellular mechanisms underlying the epithelial actions of adenosine, we studied adenosine receptor-effector coupling in cultured rabbit cortical collecting tubule (RCCT) cells. We previously reported, in RCCT cells isolated by immunodissection, that a potent A2 adenosine analogue [5'-N-ethylcarboxamideadenosine (NECA)] stimulates cAMP production [effective concentration 50% (EC50) = 1 microM], and potent A1 analogues [N6-cyclohexyladenosine (CHA) and R-N6-phenylisopropyladenosine (PIA)] inhibit basal and AVP-stimulated cAMP production (EC50 = 5 nM). The present study was undertaken to determine whether adenosine receptors in RCCT cells are also coupled to a signal transduction system leading to the mobilization of intracellular free calcium. RCCT cells were loaded with the fluorescent calcium indicator, fura-2, and were treated with the adenosine analogues NECA, CHA, and PIA. All three adenosine analogues produced dose-dependent (1 nM-0.1 mM), transient increases in intracellular calcium concentration with equal potency (EC50 = 0.5 microM). Chelation of extracellular calcium with ethyleneglycol-bis(beta-aminoethyl ether)N,N,N',N' tetraacetic acid (EGTA) did not abolish the increase in calcium. The adenosine receptor antagonists, 1,3-diethyl-8-propylxanthine and 8-cyclopentyl-1,3-dipropylxanthine, and pretreatment of RCCT cells with pertussis toxin blocked the increase in calcium. These results demonstrate that RCCT cells have, in addition to adenosine receptors associated with the stimulation and inhibition of cAMP, a pertussis-toxin sensitive receptor system that leads to the mobilization of intracellular calcium.

Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A

Tetrahedron ◽  
2016 ◽  
Vol 72 (27-28) ◽  
pp. 3823-3831 ◽  
Author(s):  
Ruwen Yin ◽  
Wei Zhang ◽  
Guoyun Liu ◽  
Ping Wu ◽  
Choiwan Lau ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Biological Evaluation

scholarly journals Adenosine Analogues Depress Ventilation in Rabbit Neonates. Theophylline Stimulation of Respiration via Adenosine Receptors?

1984 ◽  
Vol 18 (4) ◽  
pp. 387-390 ◽  
Author(s):  
H Lagercrantz ◽  
Y Yamamoto ◽  
B B Fredholm ◽  
N R Prabhakar ◽  
C von Euler
Keyword(s):  
Adenosine Receptors ◽  
Adenosine Analogues ◽  
Stimulation Of

Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3and Their 20-Epimers:  Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20

2000 ◽  
Vol 43 (22) ◽  
pp. 4247-4265 ◽  
Author(s):  
Katsuhiro Konno ◽  
Toshie Fujishima ◽  
Shojiro Maki ◽  
Zhaopeng Liu ◽  
Daishiro Miura ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Biological Evaluation

Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors

2000 ◽  
Vol 10 (3) ◽  
pp. 209-211 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Barbara Cacciari ◽  
Romeo Romagnoli ◽  
Katia Varani ◽  
Stefania Merighi ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Biological Evaluation ◽  
High Affinity

Synthesis, Conformational Analysis, and Biological Evaluation of 19-nor-Vitamin D3Analogues with A-Ring Modifications

2009 ◽  
Vol 52 (19) ◽  
pp. 6158-6162 ◽  
Author(s):  
Laura Sánchez-Abella ◽  
Susana Fernández ◽  
Annemieke Verstuyf ◽  
Lieve Verlinden ◽  
Vicente Gotor ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Biological Evaluation

Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexylindolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes

2008 ◽  
Vol 51 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Ryo C. Yanagita ◽  
Yu Nakagawa ◽  
Nobuhiro Yamanaka ◽  
Kaori Kashiwagi ◽  
Naoaki Saito ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Conformational Analysis ◽  
Biological Evaluation ◽  
Kinase C ◽  
Novel Protein

Adjusting the Structure of 2′-Modified Nucleosides and Oligonucleotides via C4′-α-F or C4′-α-OMe Substitution: Synthesis and Conformational Analysis

2018 ◽  
Vol 83 (17) ◽  
pp. 9839-9849 ◽  
Author(s):  
Elise Malek-Adamian ◽  
Mihai Burai Patrascu ◽  
Sunit Kumar Jana ◽  
Saúl Martínez-Montero ◽  
Nicolas Moitessier ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Modified Nucleosides

N6-1,3-Diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

2008 ◽  
Vol 43 (8) ◽  
pp. 1639-1647 ◽  
Author(s):  
Irene Giorgi ◽  
Giuliana Biagi ◽  
Anna Maria Bianucci ◽  
Alice Borghini ◽  
Oreste Livi ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Biological Evaluation ◽  
Allosteric Modulators ◽  
A2a Adenosine Receptors ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document