Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexylindolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes

2008 ◽  
Vol 51 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Ryo C. Yanagita ◽  
Yu Nakagawa ◽  
Nobuhiro Yamanaka ◽  
Kaori Kashiwagi ◽  
Naoaki Saito ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Conformational Analysis ◽  
Biological Evaluation ◽  
Kinase C ◽  
Novel Protein

Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety

1999 ◽  
Vol 9 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Yasuyuki Endo ◽  
Masako Shimazu ◽  
Hiroshi Fukasawa ◽  
Paul E. Driedger ◽  
Kaname Kimura ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Computer Modeling ◽  
Biological Evaluation ◽  
Kinase C ◽  
Novel Protein

ChemInform Abstract: Synthesis, Computer Modeling and Biological Evaluation of Novel Protein Kinase C Agonists Based on a 7-Membered Lactam Moiety.

ChemInform ◽  
2010 ◽  
Vol 30 (20) ◽  
pp. no-no
Author(s):  
Yasuyuki Endo ◽  
Masako Shimazu ◽  
Hiroshi Fukasawa ◽  
Paul E. Driedger ◽  
Kaname Kimura ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Computer Modeling ◽  
Biological Evaluation ◽  
Kinase C ◽  
Novel Protein

scholarly journals Physiological Role for Phosphatidic Acid in the Translocation of the Novel Protein Kinase C Apl II in Aplysia Neurons

2008 ◽  
Vol 28 (15) ◽  
pp. 4719-4733 ◽  
Author(s):  
Carole A. Farah ◽  
Ikue Nagakura ◽  
Daniel Weatherill ◽  
Xiaotang Fan ◽  
Wayne S. Sossin
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phosphatidic Acid ◽  
Physiological Role ◽  
C2 Domain ◽  
The Novel ◽  
Physiological Conditions ◽  
Kinase C ◽  
Neuronal Membranes ◽  
Novel Protein

ABSTRACT In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. The orthologue of PKC Apl II, PKCε, has been reported to require phosphatidic acid (PA) in conjunction with diacylglycerol (DAG) for translocation. We find that PKC Apl II can be synergistically translocated to membranes by the combination of DAG and PA. We identify a mutation in the C1b domain (arginine 273 to histidine; PKC Apl II-R273H) that removes the effects of exogenous PA. In Aplysia neurons, the inhibition of endogenous PA production by 1-butanol inhibited the physiological translocation of PKC Apl II by serotonin in the cell body and at the synapse but not the translocation of PKC Apl II-R273H. The translocation of PKC Apl II-R273H in the absence of PA was explained by two additional effects of this mutation: (i) the mutation removed C2 domain-mediated inhibition, and (ii) the mutation decreased the concentration of DAG required for PKC Apl II translocation. We present a model in which, under physiological conditions, PA is important to activate the novel PKC Apl II both by synergizing with DAG and removing C2 domain-mediated inhibition.

Rictor regulates phosphorylation of the novel protein kinase C Apl II in Aplysia sensory neurons

2012 ◽  
Vol 122 (6) ◽  
pp. 1108-1117 ◽  
Author(s):  
Margaret Labban ◽  
John R. Dyer ◽  
Wayne S. Sossin
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Sensory Neurons ◽  
The Novel ◽  
Kinase C ◽  
Novel Protein

scholarly journals Novel Protein Kinase C δ Isoform Insensitive to Caspase-3

2001 ◽  
Vol 24 (9) ◽  
pp. 973-977 ◽  
Author(s):  
Yoshiaki SAKURAI ◽  
Yoshiaki ONISHI ◽  
Yutaka TANIMOTO ◽  
Harutoshi KIZAKI
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Caspase 3 ◽  
Kinase C ◽  
Novel Protein

Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C

1993 ◽  
Vol 115 (10) ◽  
pp. 3957-3965 ◽  
Author(s):  
Alan P. Kozikowski ◽  
Dawei Ma ◽  
Yuan Ping Pang ◽  
Patrick Shum ◽  
Vladimir Likic ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Molecular Modeling ◽  
Protein Kinase ◽  
Biological Evaluation ◽  
Kinase C

Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer

Phytomedicine ◽  
2019 ◽  
Vol 65 ◽  
pp. 153100 ◽  
Author(s):  
Yuwei Wang ◽  
Chunping Tang ◽  
Sheng Yao ◽  
Huanling Lai ◽  
Runze Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Kinase C ◽  
Croton Tiglium ◽  
Novel Protein

Role of novel protein kinase C in neuroendocrine-immune regulatory network in haemocytes of Litopenaeus vannamei: An in vitro approach

2020 ◽  
Vol 105 ◽  
pp. 53-61
Author(s):  
Zhong-Wen Chang ◽  
Yi-Chun Yeh ◽  
Chin-Chyuan Chang
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Litopenaeus Vannamei ◽  
Regulatory Network ◽  
Kinase C ◽  
Novel Protein
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