Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 7. Direct Modification of (+)-Artemisinin and In Vivo Antimalarial Screening of New, Potential Preclinical Antimalarial Candidates

2002 ◽  
Vol 45 (19) ◽  
pp. 4321-4335 ◽  
Author(s):  
Mitchell A. Avery ◽  
Maria Alvim-Gaston ◽  
Jeffrey A. Vroman ◽  
Baogen Wu ◽  
Arba Ager ◽  
...  
Keyword(s):  
Antimalarial Agent ◽  
Structure Activity Relationships ◽  
Direct Modification ◽  
Structure Activity

Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 4. Effect of Substitution at C-3

1996 ◽  
Vol 39 (15) ◽  
pp. 2900-2906 ◽  
Author(s):  
Mitchell A. Avery ◽  
Sanjiv Mehrotra ◽  
Jason D. Bonk ◽  
Jeffrey A. Vroman ◽  
D. Keith Goins ◽  
...  
Keyword(s):  
Antimalarial Agent ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Structure-Activity Relationships of 1,3-Benzoxazole-4-carbonitriles as Novel Antifungal Agents with Potent in vivo Efficacy.

ChemInform ◽  
2011 ◽  
Vol 42 (35) ◽  
pp. no-no
Author(s):  
Jun-ichi Kuroyanagi ◽  
Kazuo Kanai ◽  
Takao Horiuchi ◽  
Hiroshi Takeshita ◽  
Shozo Kobayashi ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
In Vivo Efficacy ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

In Vivo and in Vitro Structure-Activity Relationships and Structural Conformation of Kisspeptin-10-Related Peptides

2009 ◽  
Vol 76 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Ester Gutiérrez-Pascual ◽  
Jérôme Leprince ◽  
Antonio J. Martínez-Fuentes ◽  
Isabelle Ségalas-Milazzo ◽  
Rafael Pineda ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structural Conformation ◽  
Structure Activity

Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole

1989 ◽  
Vol 44 (1-2) ◽  
pp. 85-96 ◽  
Author(s):  
E. Ebert ◽  
W. Eckhardt ◽  
K. Jäkel ◽  
D. Sozzi ◽  
C. Vogel ◽  
...  
Keyword(s):  
Fungicidal Activity ◽  
Quantitative Structure ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Quantitative Structure Activity Relationships

Abstract The preparation of the four stereoisomers of propiconazole (TILT®) is described. Their inhibition of the 14α-C-demethylation of the sterol nucleus is examined and compared with the inhibition by the four stereoisomers of etaconazole (SONAX®). The quantitative structure-activity relationships (QSAR) of substituted 1,3-dioxolane-2-yl-methyltriazoles and 1,3-dioxane-2-ylmethyltriazoles on in vivo fungicidal activity are investigated.

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