Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

2003 ◽  
Vol 46 (12) ◽  
pp. 2376-2396 ◽  
Author(s):  
Venkatesan Aranapakam ◽  
Jamie M. Davis ◽  
George T. Grosu ◽  
Baker ◽  
John Ellingboe ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Hydroxamic Acids ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Matrix Metalloproteinase Inhibitors ◽  
Active Matrix ◽  
Structure Activity ◽  
Metalloproteinase Inhibitors ◽  
Relationship Of ◽  
Orally Active
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