scholarly journals Synthesis and Structure−Activity Relationships of Conformationally Constrained Histamine H3Receptor Agonists

2003 ◽  
Vol 46 (25) ◽  
pp. 5445-5457 ◽  
Author(s):  
Ruengwit Kitbunnadaj ◽  
Obbe P. Zuiderveld ◽  
Iwan J. P. De Esch ◽  
Roeland C. Vollinga ◽  
Remko Bakker ◽  
...  
Keyword(s):  
Conformationally Constrained ◽  
Structure Activity Relationships ◽  
Structure Activity

Preparation of Racemic cis- and trans-2-(2-Alkoxyphenylcarbamoyloxy)cycloheptylmethylpiperidinium Chlorides

1994 ◽  
Vol 59 (3) ◽  
pp. 675-682 ◽  
Author(s):  
Fridrich Gregáň ◽  
Viktor Kettmann ◽  
Pavol Novomeský ◽  
Július Sivý
Keyword(s):  
Fractional Crystallization ◽  
Local Anesthetics ◽  
Conformationally Constrained ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Cis And Trans

The synthesis of two pairs of the title diastereomers, which represent conformationally constrained analogues of the phenylcarbamate local anesthetics, is described. The synthesis was accomplished by starting from cycloheptanone and 2-alkoxyanilines and the intermediate diastereomers of 2-aminomethylcycloalkanols (VI, VII) were separated as their 4-nitrobenzoyl derivatives (IV, V) by extraction and fractional crystallization. The prepared compounds (VIIIa, VIIIb, IXa, and IXb) are assumed to be of help in interpreting the structure activity relationships within this class of drugs.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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