1-Methyl-3H-pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis, and Biological Activity of New Antitumor Agents

2005 ◽  
Vol 48 (8) ◽  
pp. 2859-2866 ◽  
Author(s):  
Anna Maria Almerico ◽  
Francesco Mingoia ◽  
Patrizia Diana ◽  
Paola Barraja ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis

scholarly journals Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents

2015 ◽  
Vol 58 (19) ◽  
pp. 7749-7762 ◽  
Author(s):  
Yongseok Kwon ◽  
Jayoung Song ◽  
Honggu Lee ◽  
Eun-Yeong Kim ◽  
Kiho Lee ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
Orally Active

scholarly journals Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

2011 ◽  
Vol 21 (1) ◽  
pp. 546-549 ◽  
Author(s):  
Yizhou Dong ◽  
Kyoko Nakagawa-Goto ◽  
Chin-Yu Lai ◽  
Susan L. Morris-Natschke ◽  
Kenneth F. Bastow ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Antitumor Agents ◽  
Design Synthesis

Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro

2018 ◽  
Vol 93 (6) ◽  
pp. 986-992
Author(s):  
Xian H. Wang ◽  
Mei Huang ◽  
Chang K. Zhao ◽  
Chan Li ◽  
Lang Xu
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
Activity Evaluation

Design, Synthesis and Biological Activity of (20 S ,21 S )‐7‐Cyclohexyl‐21‐fluorocamptothecin Carbamates as Potential Antitumor Agents

2020 ◽  
Vol 17 (7) ◽  
Author(s):  
Haijun Ma ◽  
Baobao Chen ◽  
Yuan Wang ◽  
Chuanhao Wang ◽  
Jianzhong Yao ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
Potential Antitumor

Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine derivatives as potent antitumor agents

2019 ◽  
Vol 43 (25) ◽  
pp. 10190-10202 ◽  
Author(s):  
Gang Hu ◽  
Chu Wang ◽  
Xin Xin ◽  
Shuaikang Li ◽  
Zefei Li ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Two series of 2-aminopyrimidine derivatives possessing triazolopiperazine or 1,4,8-triazaspiro[4.5]decan-3-one scaffolds were designed, synthesized and evaluated for their biological activity.

scholarly journals Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents

2020 ◽  
Vol 44 (9-10) ◽  
pp. 536-542
Author(s):  
Wen Li ◽  
Shu-Yi Chen ◽  
Wei-Nan Hu ◽  
Mei Zhu ◽  
Jia-Min Liu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Substitution Reactions ◽  
Migration Ability ◽  
Design Synthesis ◽  
Excellent Activity ◽  
Quinazoline Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Antiproliferative Activities

A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib.

Design, Synthesis and Biological Activity of Aromatic Diketone Derivatives as HIV-1 Integrase Inhibitors

2015 ◽  
Vol 11 (2) ◽  
pp. 180-187 ◽  
Author(s):  
Liming Hu ◽  
Zhipeng Li ◽  
Zhanyang Wang ◽  
Gengxin Liu ◽  
Xianzhuo He ◽  
...  
Keyword(s):  
Biological Activity ◽  
Integrase Inhibitors ◽  
Design Synthesis ◽  
Hiv 1

Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents

2011 ◽  
Vol 7 (4) ◽  
pp. 295-300
Author(s):  
Youguang Zheng ◽  
Min Sun ◽  
Yi Liu ◽  
Mingdong Li ◽  
Min Ji
Keyword(s):  
Antitumor Agents ◽  
Design Synthesis ◽  
Potential Antitumor

Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity

2021 ◽  
Vol 35 ◽  
pp. 116072 ◽  
Author(s):  
Hae Ju Han ◽  
Woong Sub Byun ◽  
Gyu Ho Lee ◽  
Won Kyung Kim ◽  
Kyungkuk Jang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Inhibitory Activity ◽  
Antitumor Agents
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