Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Zhonghua Pei; Xiaofeng Li; Thomas W. von Geldern; Kenton Longenecker; Daisy Pireh; Kent D. Stewart; Bradley J. Backes; Chunqiu Lai; Thomas H. Lubben; Stephen J. Ballaron; David W. A. Beno; Anita J. Kempf-Grote; Hing L. Sham; James M. Trevillyan

doi:10.1021/jm061436d

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm061436d ◽

2007 ◽

Vol 50 (8) ◽

pp. 1983-1987 ◽

Cited By ~ 55

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Thomas W. von Geldern ◽

Kenton Longenecker ◽

Daisy Pireh ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors.

ChemInform ◽

10.1002/chin.200903194 ◽

2009 ◽

Vol 40 (3) ◽

Author(s):

Hiroshi Fukushima ◽

Akira Hiratate ◽

Masato Takahashi ◽

Masako Saito-Hori ◽

Eiji Munetomo ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Structure–activity relationships study on biological activity of peptides as dipeptidyl peptidase IV inhibitors by chemometric modeling

Chemical Biology & Drug Design ◽

10.1111/cbdd.13643 ◽

2019 ◽

Vol 95 (2) ◽

pp. 291-301 ◽

Cited By ~ 2

Author(s):

Paulina Kęska ◽

Joanna Stadnik

Keyword(s):

Biological Activity ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Synthesis and structure–activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.09.010 ◽

2004 ◽

Vol 12 (23) ◽

pp. 6053-6061 ◽

Cited By ~ 24

Author(s):

Hiroshi Fukushima ◽

Akira Hiratate ◽

Masato Takahashi ◽

Masako Saito ◽

Eiji Munetomo ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Dipeptidyl Peptidase IV Inhibitors with the N-terminal MXP Sequence: Structure-Activity-Relationships

Dipeptidyl Aminopeptidases in Health and Disease - Advances in Experimental Medicine and Biology ◽

10.1007/0-306-47920-6_21 ◽

2005 ◽

pp. 175-179

Author(s):

Jürgen Faust ◽

Petra Fuchs ◽

Sabine Wrenger ◽

Dirk Reinhold ◽

Angela Stöckel-Maschek ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Sequence Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Synthesis and Structure–Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.56.1110 ◽

2008 ◽

Vol 56 (8) ◽

pp. 1110-1117 ◽

Cited By ~ 9

Author(s):

Hiroshi Fukushima ◽

Akira Hiratate ◽

Masato Takahashi ◽

Masako Saito-Hori ◽

Eiji Munetomo ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Synthesis and structure–activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.01.016 ◽

2008 ◽

Vol 16 (7) ◽

pp. 4093-4106 ◽

Cited By ~ 26

Author(s):

Hiroshi Fukushima ◽

Akira Hiratate ◽

Masato Takahashi ◽

Ayako Mikami ◽

Masako Saito-Hori ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Structure−Activity Relationship of Diaryl Phosphonate Esters as Potent Irreversible Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm981033g ◽

1999 ◽

Vol 42 (6) ◽

pp. 1041-1052 ◽

Cited By ~ 63

Author(s):

Alexander Belyaev ◽

Xuemei Zhang ◽

Koen Augustyns ◽

Anne-Marie Lambeir ◽

Ingrid De Meester ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors ◽

Phosphonate Esters ◽

Relationship Of

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Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.

Journal of Medicinal Chemistry ◽

10.1021/jm060818g ◽

2006 ◽

Vol 49 (17) ◽

pp. 5387-5387

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Kenton Longenecker ◽

Thomas W. von Geldern ◽

Paul E. Wiedeman ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Pharmacological Evaluation ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm051283e ◽

2006 ◽

Vol 49 (12) ◽

pp. 3520-3535 ◽

Cited By ~ 40

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Kenton Longenecker ◽

Thomas W. von Geldern ◽

Paul E. Wiedeman ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Pharmacological Evaluation ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Synthesis, Structure-Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole-3-Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2012.01365.x ◽

2012 ◽

Vol 79 (6) ◽

pp. 897-906 ◽

Cited By ~ 12

Author(s):

Deyan Wu ◽

Fangfang Jin ◽

Weiqiang Lu ◽

Jin Zhu ◽

Cui Li ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Pharmacophore Modeling ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Modeling Studies ◽

Dipeptidyl Peptidase Iv Inhibitors

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