Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.

Zhonghua Pei; Xiaofeng Li; Kenton Longenecker; Thomas W. von Geldern; Paul E. Wiedeman; Thomas H. Lubben; Bradley A. Zinker; Kent Stewart; Stephen J. Ballaron; Michael A. Stashko; Amanda K. Mika; David W. A. Beno; Michelle Long; Heidi Wells; Anita J. Kempf-Grote; David J. Madar; Todd S. McDermott; Lakshmi Bhagavatula; Michael G. Fickes; Daisy Pireh; Larry R. Solomon; Marc R. Lake; Rohinton Edalji; Elizabeth H. Fry; Hing L. Sham; James M. Trevillyan

doi:10.1021/jm060818g

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors.

Journal of Medicinal Chemistry ◽

10.1021/jm060818g ◽

2006 ◽

Vol 49 (17) ◽

pp. 5387-5387

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Kenton Longenecker ◽

Thomas W. von Geldern ◽

Paul E. Wiedeman ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Pharmacological Evaluation ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm051283e ◽

2006 ◽

Vol 49 (12) ◽

pp. 3520-3535 ◽

Cited By ~ 40

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Kenton Longenecker ◽

Thomas W. von Geldern ◽

Paul E. Wiedeman ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Pharmacological Evaluation ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Structure−Activity Relationship of Diaryl Phosphonate Esters as Potent Irreversible Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm981033g ◽

1999 ◽

Vol 42 (6) ◽

pp. 1041-1052 ◽

Cited By ~ 63

Author(s):

Alexander Belyaev ◽

Xuemei Zhang ◽

Koen Augustyns ◽

Anne-Marie Lambeir ◽

Ingrid De Meester ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors ◽

Phosphonate Esters ◽

Relationship Of

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Synthesis, Structure-Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole-3-Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2012.01365.x ◽

2012 ◽

Vol 79 (6) ◽

pp. 897-906 ◽

Cited By ~ 12

Author(s):

Deyan Wu ◽

Fangfang Jin ◽

Weiqiang Lu ◽

Jin Zhu ◽

Cui Li ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Pharmacophore Modeling ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Modeling Studies ◽

Dipeptidyl Peptidase Iv Inhibitors

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The dipeptidyl peptidase IV inhibitory activity and multifunctional antidiabetic properties of SQSPA: Structure – Activity relationship evaluated with alanine scanning

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.05.250 ◽

2020 ◽

Vol 160 ◽

pp. 1220-1229

Author(s):

Mohammed Auwal Ibrahim ◽

June C. Serem ◽

Megan J. Bester ◽

Anabella R.M. Gaspar

Keyword(s):

Inhibitory Activity ◽

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Alanine Scanning ◽

Structure Activity

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Pyrrolidides: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(97)89082-4 ◽

1997 ◽

Vol 32 (4) ◽

pp. 301-309 ◽

Cited By ~ 25

Author(s):

K.J.L. Augustyns ◽

A.M. Lambeir ◽

M Borloo ◽

I De Meester ◽

I Vedernikova ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity

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Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity

Peptides ◽

10.1016/j.peptides.2016.03.005 ◽

2016 ◽

Vol 79 ◽

pp. 1-7 ◽

Cited By ~ 45

Author(s):

Alice B. Nongonierma ◽

Richard J. FitzGerald

Keyword(s):

Inhibitory Activity ◽

Milk Protein ◽

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Dpp Iv

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Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure–Activity Relationship

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.0c04974 ◽

2020 ◽

Vol 68 (43) ◽

pp. 12141-12151

Author(s):

Fengyi Gao ◽

Yishan Fu ◽

Junjie Yi ◽

Anning Gao ◽

Yijia Jia ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Structure Activity Relationship ◽

Dipeptidyl Peptidase Iv ◽

Activity Relationship ◽

Structure Activity ◽

Dietary Flavonoids

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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm061436d ◽

2007 ◽

Vol 50 (8) ◽

pp. 1983-1987 ◽

Cited By ~ 55

Author(s):

Zhonghua Pei ◽

Xiaofeng Li ◽

Thomas W. von Geldern ◽

Kenton Longenecker ◽

Daisy Pireh ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors.

ChemInform ◽

10.1002/chin.200903194 ◽

2009 ◽

Vol 40 (3) ◽

Author(s):

Hiroshi Fukushima ◽

Akira Hiratate ◽

Masato Takahashi ◽

Masako Saito-Hori ◽

Eiji Munetomo ◽

...

Keyword(s):

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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Structure–activity relationships study on biological activity of peptides as dipeptidyl peptidase IV inhibitors by chemometric modeling

Chemical Biology & Drug Design ◽

10.1111/cbdd.13643 ◽

2019 ◽

Vol 95 (2) ◽

pp. 291-301 ◽

Cited By ~ 2

Author(s):

Paulina Kęska ◽

Joanna Stadnik

Keyword(s):

Biological Activity ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Structure Activity Relationships ◽

Structure Activity ◽

Dipeptidyl Peptidase Iv Inhibitors

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