Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

2010 ◽  
Vol 53 (19) ◽  
pp. 7076-7094 ◽  
Author(s):  
R. Matthew Cross ◽  
Andrii Monastyrskyi ◽  
Tina S. Mutka ◽  
Jeremy N. Burrows ◽  
Dennis E. Kyle ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Structure Property ◽  
Property Relationship ◽  
Structure Activity ◽  
Structure Property Relationship

Structure-Activity and Structure-Property Relationship Studies of Spirocyclic Chromanes with Antimalarial Activity

2022 ◽  
pp. 116629
Author(s):  
Iredia D. Iyamu ◽  
Yingzhao Zhao ◽  
Prakash T. Parvatkar ◽  
Bracken F. Roberts ◽  
Debora R. Cassandra ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Structure Property ◽  
Property Relationship ◽  
Structure Activity ◽  
Structure Property Relationship

Exploration of Bis(Arylimidazole) Iridium Picolinate Complexes

2017 ◽  
Author(s):  
Aron Huckaba ◽  
sadig aghazada ◽  
iwan zimmermann ◽  
giulia grancini ◽  
natalia gasilova ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Photophysical Properties ◽  
Structure Property ◽  
Aryl Group ◽  
Ligand Modification ◽  
Property Relationship ◽  
Structure Property Relationship

The straightforward synthesis and photophysical properties of a new series of heteroleptic Iridium (III) bis(2-arylimidazole) picolinate complexes is reported. Each complex has been characterized by NMR, UV-Vis, cyclic voltammetry, and the emissive properties of each is described. By systematically modifying first the cyclometallating aryl group on the arylimidazole ligand and then the picolinate ligand, the ramifications of ligand modification in these complexes was better understood through the construction of a structure-property relationship.

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