Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy†

Ángel L. Orcajo-Rincón; Silvia Ortega-Gutiérrez; Pedro Serrano; Ivan R. Torrecillas; Kurt Wüthrich; Mercedes Campillo; Leonardo Pardo; Alma Viso; Bellinda Benhamú; María L. López-Rodríguez

doi:10.1021/jm101478n

Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy†

Journal of Medicinal Chemistry ◽

10.1021/jm101478n ◽

2011 ◽

Vol 54 (4) ◽

pp. 1096-1100 ◽

Cited By ~ 5

Author(s):

Ángel L. Orcajo-Rincón ◽

Silvia Ortega-Gutiérrez ◽

Pedro Serrano ◽

Ivan R. Torrecillas ◽

Kurt Wüthrich ◽

...

Keyword(s):

Molecular Modeling ◽

Nmr Spectroscopy ◽

Growth Factor ◽

Growth Factor Receptor ◽

Peptide Ligands ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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Nuclear Magnetic Resonance Solution Structure of the Growth Factor Receptor-Bound Protein 2 Src Homology 2 Domain

Biochemistry ◽

10.1021/bi952615s ◽

1996 ◽

Vol 35 (36) ◽

pp. 11852-11864 ◽

Cited By ~ 12

Author(s):

Kevin H. Thornton ◽

W. Tom Mueller ◽

Patrick McConnell ◽

Guochang Zhu ◽

Alan R. Saltiel ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Growth Factor ◽

Magnetic Resonance ◽

Solution Structure ◽

Growth Factor Receptor ◽

Src Homology 2 ◽

Resonance Solution ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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Selectivity and Mechanism of Action of a Growth Factor Receptor-Bound Protein 2 Src Homology 2 Domain Binding Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm800523u ◽

2008 ◽

Vol 51 (23) ◽

pp. 7459-7468 ◽

Cited By ~ 7

Author(s):

Alessio Giubellino ◽

Zhen-Dan Shi ◽

Lisa M. Miller Jenkins ◽

Karen M. Worthy ◽

Lakshman K. Bindu ◽

...

Keyword(s):

Growth Factor ◽

Mechanism Of Action ◽

Growth Factor Receptor ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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p66shc Negatively Regulates Insulin-Like Growth Factor I Signal Transduction via Inhibition of p52shc Binding to Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Leading to Impaired Growth Factor Receptor-Bound Protein-2 Membrane Recruitment

Molecular Endocrinology ◽

10.1210/me.2008-0079 ◽

2008 ◽

Vol 22 (9) ◽

pp. 2162-2175 ◽

Cited By ~ 37

Author(s):

Gang Xi ◽

Xinchun Shen ◽

David R. Clemmons

Keyword(s):

Growth Factor ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Growth Factor Receptor ◽

Membrane Recruitment ◽

Factor I ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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Inhibition of Tumor Metastasis by a Growth Factor Receptor Bound Protein 2 Src Homology 2 Domain–Binding Antagonist

Cancer Research ◽

10.1158/0008-5472.can-07-0022 ◽

2007 ◽

Vol 67 (13) ◽

pp. 6012-6016 ◽

Cited By ~ 29

Author(s):

Alessio Giubellino ◽

Yang Gao ◽

Sunmin Lee ◽

Min-Jung Lee ◽

James R. Vasselli ◽

...

Keyword(s):

Growth Factor ◽

Tumor Metastasis ◽

Growth Factor Receptor ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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Growth Factor Receptor-bound Protein 2 Interaction with the Tyrosine-phosphorylated Tail of Amyloid β Precursor Protein Is Mediated by Its Src Homology 2 Domain

Journal of Biological Chemistry ◽

10.1074/jbc.m400488200 ◽

2004 ◽

Vol 279 (24) ◽

pp. 25374-25380 ◽

Cited By ~ 33

Author(s):

Dawang Zhou ◽

Cristiana Noviello ◽

Chiara D'Ambrosio ◽

Andrea Scaloni ◽

Luciano D'Adamio

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Amyloid Β ◽

Precursor Protein ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Growth Factor Receptor Bound

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Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53920-x ◽

1993 ◽

Vol 268 (3) ◽

pp. 1775-1779 ◽

Cited By ~ 1

Author(s):

G. Zhu ◽

S.J. Decker ◽

B.J. Mayer ◽

A.R. Saltiel

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Direct Analysis ◽

Src Homology 2 ◽

Src Homology ◽

Epidermal Growth ◽

Src Homology 2 Domain

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The Src Homology 2 Domain of Rin1 Mediates Its Binding to the Epidermal Growth Factor Receptor and Regulates Receptor Endocytosis

Journal of Biological Chemistry ◽

10.1074/jbc.m304324200 ◽

2003 ◽

Vol 278 (34) ◽

pp. 32027-32036 ◽

Cited By ~ 65

Author(s):

M. Alejandro Barbieri ◽

Chen Kong ◽

Pin-I Chen ◽

Bruce F. Horazdovsky ◽

Philip D. Stahl

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Endocytosis ◽

Src Homology 2 ◽

Src Homology ◽

Epidermal Growth ◽

Src Homology 2 Domain

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Design and Synthesis of 4-(α-Hydroxymalonyl)phenylalanine as a New Phosphotyrosyl Mimetic and Its Use in Growth Factor Receptor Bound 2 Src-Homology 2 (Grb2 SH2) Domain-Binding Peptides

Journal of Medicinal Chemistry ◽

10.1021/jm050154v ◽

2005 ◽

Vol 48 (16) ◽

pp. 5369-5372 ◽

Cited By ~ 5

Author(s):

Sang-Uk Kang ◽

Karen M. Worthy ◽

Lakshman K. Bindu ◽

Manchao Zhang ◽

Dajun Yang ◽

...

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Sh2 Domain ◽

Design And Synthesis ◽

Src Homology 2 ◽

Src Homology ◽

Binding Peptides ◽

Growth Factor Receptor Bound

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Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.89.24.11673 ◽

1992 ◽

Vol 89 (24) ◽

pp. 11673-11677 ◽

Cited By ~ 20

Author(s):

M. Overduin ◽

B. Mayer ◽

C. B. Rios ◽

D. Baltimore ◽

D. Cowburn

Keyword(s):

Nmr Spectroscopy ◽

Secondary Structure ◽

Heteronuclear Nmr ◽

Src Homology 2 ◽

Heteronuclear Nmr Spectroscopy ◽

Src Homology ◽

Src Homology 2 Domain

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Affinity chromatography for purification of the modular protein growth factor receptor-bound protein 2 and development of a screening test for growth factor receptor-bound protein 2 Src homology 3 domain inhibitor using peroxidase-linked ligand

Analytical Biochemistry ◽

10.1016/j.ab.2005.12.032 ◽

2006 ◽

Vol 351 (1) ◽

pp. 93-99 ◽

Cited By ~ 2

Author(s):

B. Gril ◽

W.Q. Liu ◽

C. Lenoir ◽

C. Garbay ◽

M. Vidal

Keyword(s):

Growth Factor ◽

Affinity Chromatography ◽

Screening Test ◽

Growth Factor Receptor ◽

Src Homology 3 ◽

Src Homology 3 Domain ◽

Src Homology ◽

Growth Factor Receptor Bound

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