Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Journal of Medicinal Chemistry ◽

10.1021/jm201139r ◽

2012 ◽

Vol 55 (4) ◽

pp. 1445-1464 ◽

Author(s):

Bruce J. Melancon ◽

Corey R. Hopkins ◽

Michael R. Wood ◽

Kyle A. Emmitte ◽

Colleen M. Niswender ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Allosteric Modulation ◽

Central Nervous System Drug

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Faculty Opinions recommendation of Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13945959.15401060 ◽

2012 ◽

Author(s):

Peter R Bernstein

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Allosteric Modulation ◽

Central Nervous System Drug

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Faculty Opinions recommendation of Demystifying brain penetration in central nervous system drug discovery. Miniperspective.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717963953.793466447 ◽

2012 ◽

Author(s):

Jefferson Tilley

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Central Nervous System Drug ◽

Brain Penetration

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Faculty Opinions recommendation of Demystifying brain penetration in central nervous system drug discovery. Miniperspective.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717963953.793465593 ◽

2012 ◽

Author(s):

John Lowe

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Central Nervous System Drug ◽

Brain Penetration

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ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

BMC Neurology ◽

10.1186/1471-2377-9-s1-s1 ◽

2009 ◽

Vol 9 (Suppl 1) ◽

pp. S1 ◽

Author(s):

Katya Tsaioun ◽

Michel Bottlaender ◽

Aloise Mabondzo ◽

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Drug Development ◽

Central Nervous System Drug

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Demystifying Brain Penetration in Central Nervous System Drug Discovery

Journal of Medicinal Chemistry ◽

10.1021/jm301297f ◽

2012 ◽

Vol 56 (1) ◽

pp. 2-12 ◽

Author(s):

Li Di ◽

Haojing Rong ◽

Bo Feng

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Central Nervous System Drug ◽

Brain Penetration

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Can functional magnetic resonance imaging improve success rates in central nervous system drug discovery?

Expert Opinion on Drug Discovery ◽

10.1517/17460441.2011.584529 ◽

2011 ◽

Vol 6 (6) ◽

pp. 597-617 ◽

Author(s):

David Borsook ◽

Richard J Hargreaves ◽

Lino Becerra

Keyword(s):

Magnetic Resonance Imaging ◽

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Success Rates ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Central Nervous System Drug

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Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2006.05.012 ◽

2006 ◽

Vol 112 (3) ◽

pp. 677-700 ◽

Author(s):

Charles D. Nichols

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drosophila Melanogaster ◽

Drug Discovery ◽

Central Nervous System Drug

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Faculty Opinions recommendation of Challenges and Opportunities in Central Nervous System Drug Discovery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735891377.793560695 ◽

2019 ◽

Author(s):

Dario Doller

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Central Nervous System Drug ◽

Challenges And Opportunities

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Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2010.00777.x ◽

2010 ◽

Vol 160 (3) ◽

pp. 454-466 ◽

Author(s):

Tricia H Smith ◽

Laura J Sim-Selley ◽

Dana E Selley

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Cb1 Receptor ◽

Interacting Proteins ◽

Cannabinoid Cb1 Receptor ◽

Central Nervous System Drug ◽

Novel Targets ◽

Receptor Interacting Proteins

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Positron emission tomography in central nervous system drug discovery and development

Neuroimaging Clinics of North America ◽

10.1016/s1052-5149(03)00095-9 ◽

2003 ◽

Vol 13 (4) ◽

pp. 851-856 ◽

Author(s):

Malcolm Cooper ◽

John Metz

Keyword(s):

Positron Emission Tomography ◽

Central Nervous System ◽

Nervous System ◽

Drug Discovery ◽

Emission Tomography ◽

Central Nervous System Drug ◽

Drug Discovery And Development ◽

Positron Emission

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