Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

2015 ◽  
Vol 58 (11) ◽  
pp. 4462-4482 ◽  
Author(s):  
Nuria A. Tamayo ◽  
Mark H. Norman ◽  
Michael D. Bartberger ◽  
Fang-Tsao Hong ◽  
Yunxin Bo ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Small Molecule ◽  
Protein Interaction ◽  
Regulatory Protein ◽  
Glucokinase Regulatory Protein

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket

2014 ◽  
Vol 57 (14) ◽  
pp. 5949-5964 ◽  
Author(s):  
Fang-Tsao Hong ◽  
Mark H. Norman ◽  
Kate S. Ashton ◽  
Michael D. Bartberger ◽  
Jie Chen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Interaction ◽  
Regulatory Protein ◽  
Binding Pocket ◽  
Glucokinase Regulatory Protein

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

Nature ◽  
2013 ◽  
Vol 504 (7480) ◽  
pp. 437-440 ◽  
Author(s):  
David J. Lloyd ◽  
David J. St Jean ◽  
Robert J. M. Kurzeja ◽  
Robert C. Wahl ◽  
Klaus Michelsen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Regulatory Protein ◽  
Glucokinase Regulatory Protein ◽  
Antidiabetic Effects

Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus

Diabetes ◽  
1997 ◽  
Vol 46 (2) ◽  
pp. 179-186 ◽  
Author(s):  
K. S. Brown ◽  
S. S. Kalinowski ◽  
J. R. Megill ◽  
S. K. Durham ◽  
K. A. Mookhtiar
Keyword(s):  
Regulatory Protein ◽  
Glucokinase Regulatory Protein ◽  
Hepatocyte Nucleus
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