Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model

2008 ◽  
Vol 51 (8) ◽  
pp. 2439-2446 ◽  
Author(s):  
Hongwu Wang ◽  
Ruth A. Duffy ◽  
George C. Boykow ◽  
Samuel Chackalamannil ◽  
Vincent S. Madison
Keyword(s):  
Virtual Screening ◽  
Pharmacophore Model ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Antagonists ◽  
Cb1 Receptor Antagonists

Cannabinoid Cb1 Receptor Antagonists/Inverse Agonists and Food-Seeking Behavior

2011 ◽  
pp. 441-456
Author(s):  
John D. Salamone ◽  
Kelly Sink ◽  
Kristen N. Segovia ◽  
Patrick A. Randall ◽  
Peter J. McLaughlin ◽  
...  
Keyword(s):  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Antagonists ◽  
Inverse Agonists ◽  
Seeking Behavior ◽  
Food Seeking ◽  
Cb1 Receptor Antagonists

Identifying the structural features and diversifying the chemical domain of peripherally acting CB1 receptor antagonists using molecular modeling techniques

RSC Advances ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 1466-1483 ◽  
Author(s):  
Mayank Kumar Sharma ◽  
Prashant R. Murumkar ◽  
Guanglin Kuang ◽  
Yun Tang ◽  
Mange Ram Yadav
Keyword(s):  
Molecular Modeling ◽  
Virtual Screening ◽  
3D Qsar ◽  
Structural Features ◽  
Cb1 Receptor ◽  
Receptor Antagonists ◽  
Modeling Techniques ◽  
Qsar Models ◽  
Cb1 Receptor Antagonists

A four featured pharmacophore and predictive 3D-QSAR models were developed which were used for virtual screening of the Asinex database to get chemically diverse hits of peripherally active CB1 receptor antagonists.

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

2009 ◽  
Vol 19 (19) ◽  
pp. 5675-5678 ◽  
Author(s):  
Jos H.M. Lange ◽  
Arnold P. den Hartog ◽  
Martina A.W. van der Neut ◽  
Bernard J. van Vliet ◽  
Chris G. Kruse
Keyword(s):  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Antagonists ◽  
Cb1 Receptor Antagonists
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