Synthesis, Structure−Activity Relationships, and In Vivo Evaluation ofN3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists

2009 ◽  
Vol 52 (14) ◽  
pp. 4173-4191 ◽  
Author(s):  
Richard A. Hartz ◽  
Vijay T. Ahuja ◽  
Argyrios G. Arvanitis ◽  
Maria Rafalski ◽  
Eddy W. Yue ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
In Vivo Evaluation ◽  
Structure Activity Relationships ◽  
Crf1 Receptor ◽  
Structure Activity

Synthesis and structure–activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

2010 ◽  
Vol 20 (6) ◽  
pp. 1890-1894 ◽  
Author(s):  
Richard A. Hartz ◽  
Vijay T. Ahuja ◽  
William D. Schmitz ◽  
Thaddeus F. Molski ◽  
Gail K. Mattson ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Crf1 Receptor ◽  
Structure Activity

Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

2004 ◽  
Vol 47 (23) ◽  
pp. 5783-5790 ◽  
Author(s):  
Carolyn D. Dzierba ◽  
Amy G. Takvorian ◽  
Maria Rafalski ◽  
Padmaja Kasireddy-Polam ◽  
Harvey Wong ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists

2005 ◽  
Vol 15 (17) ◽  
pp. 3870-3873 ◽  
Author(s):  
Xiaojun Han ◽  
Jodi A. Michne ◽  
Sokhom S. Pin ◽  
Kevin D. Burris ◽  
Lynn A. Balanda ◽  
...  
Keyword(s):  
Anxiolytic Activity ◽  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity

Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists:  Structure−Activity Relationships and Computational Modeling

2007 ◽  
Vol 50 (9) ◽  
pp. 2269-2272 ◽  
Author(s):  
Carolyn D. Dzierba ◽  
Andrew J. Tebben ◽  
Richard G. Wilde ◽  
Amy G. Takvorian ◽  
Maria Rafalski ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Structure–Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques

2013 ◽  
Vol 4 (7) ◽  
pp. 596-600 ◽  
Author(s):  
Masashi Yoshimura ◽  
Masahiro Ono ◽  
Kenji Matsumura ◽  
Hiroyuki Watanabe ◽  
Hiroyuki Kimura ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Amyloid Plaques ◽  
In Vivo Evaluation ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Quinoxaline Derivatives ◽  
Β Amyloid

Rational Design, Synthesis, and Structure−Activity Relationships of Aryltriazoles as Novel Corticotropin-Releasing Factor-1 Receptor Antagonists

2005 ◽  
Vol 48 (5) ◽  
pp. 1540-1549 ◽  
Author(s):  
Richard F. Lowe ◽  
Jodene Nelson ◽  
Trunghau N. Dang ◽  
Paul D. Crowe ◽  
Anil Pahuja ◽  
...  
Keyword(s):  
Rational Design ◽  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists

2012 ◽  
Vol 22 (14) ◽  
pp. 4756-4761 ◽  
Author(s):  
Kunitoshi Takeda ◽  
Taro Terauchi ◽  
Kogyoku Shin ◽  
Mitsuhiro Ino ◽  
Hisashi Shibata ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Crf1 Receptor ◽  
Structure Activity

Synthesis and structure–activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists

2012 ◽  
Vol 20 (22) ◽  
pp. 6559-6578 ◽  
Author(s):  
Kunitoshi Takeda ◽  
Taro Terauchi ◽  
Minako Hashizume ◽  
Kohdoh Shikata ◽  
Ryota Taguchi ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
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