scholarly journals Design, Synthesis, Protein−Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance

2009 ◽  
Vol 52 (23) ◽  
pp. 7689-7705 ◽  
Author(s):  
Arun K. Ghosh ◽  
Sarang Kulkarni ◽  
David D. Anderson ◽  
Lin Hong ◽  
Abigail Baldridge ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

2017 ◽  
Vol 27 (21) ◽  
pp. 4925-4931 ◽  
Author(s):  
Arun K. Ghosh ◽  
W. Sean Fyvie ◽  
Margherita Brindisi ◽  
Melinda Steffey ◽  
Johnson Agniswamy ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation

2016 ◽  
Vol 59 (14) ◽  
pp. 6826-6837 ◽  
Author(s):  
Arun K. Ghosh ◽  
Heather L. Osswald ◽  
Kristof Glauninger ◽  
Johnson Agniswamy ◽  
Yuan-Fang Wang ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Protein X ◽  
Hiv 1

scholarly journals Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

2015 ◽  
Vol 25 (21) ◽  
pp. 4903-4909 ◽  
Author(s):  
Arun K. Ghosh ◽  
Jun Takayama ◽  
Luke A. Kassekert ◽  
Jean-Rene Ella-Menye ◽  
Sofiya Yashchuk ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

2015 ◽  
Vol 13 (48) ◽  
pp. 11607-11621 ◽  
Author(s):  
Arun K. Ghosh ◽  
Cuthbert D. Martyr ◽  
Luke A. Kassekert ◽  
Prasanth R. Nyalapatla ◽  
Melinda Steffey ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed and synthesized.

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