Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Alpha 7 ◽

P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Cited By ~ 5

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

Abstract 1624: Identification and characterization of phospho-ORM-1 as a novel nicotinic acetylcholine receptor (NAChR)-associated protein and a potential serum marker for lung cancer detection

10.1158/1538-7445.am10-1624 ◽

2010 ◽

Author(s):

Gita Jayachandran ◽

Xifeng Wu ◽

Kevin Coombes ◽

Ignacio Wistuba ◽

Jack Roth ◽

...

Keyword(s):

Lung Cancer ◽

Acetylcholine Receptor ◽

Cancer Detection ◽

Serum Marker ◽

Nicotinic Acetylcholine ◽

Lung Cancer Detection ◽

P.689 Cognitive enhancers in schizophrenia: A meta-analysis of Alpha-7 nicotinic acetylcholine receptor agonists for cognitive deficits and negative symptoms

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.09.657 ◽

2019 ◽

Vol 29 ◽

pp. S465-S466

Author(s):

M. Recio-Barbero ◽

A. Zabala ◽

R. Segarra ◽

B. Santos ◽

F.J. Ballesteros

Keyword(s):

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Negative Symptoms ◽

Meta Analysis ◽

Nicotinic Acetylcholine ◽

Cognitive Enhancers ◽

Receptor Agonists ◽

Alpha 7

Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: An effect similar to antipsychotics

Journal of Neuroscience Research ◽

10.1002/jnr.21293 ◽

2007 ◽

Vol 85 (8) ◽

pp. 1810-1818 ◽

Cited By ~ 28

Author(s):

Henrik H. Hansen ◽

Daniel B. Timmermann ◽

Dan Peters ◽

Carrie Walters ◽

M. Imad Damaj ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Rat Forebrain ◽

Alpha 7 ◽

Limbic Regions

Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists

Brain Research ◽

10.1016/s0006-8993(03)03532-7 ◽

2003 ◽

Vol 990 (1-2) ◽

pp. 203-208 ◽

Cited By ~ 52

Author(s):

Tadimeti S. Rao ◽

Lucia D. Correa ◽

Pamala Adams ◽

Emily M. Santori ◽

Aida I. Sacaan

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Serotonin Release ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine ◽

Receptor Agonists

Two distinct (-)nicotine binding sites in goldfish brain. Identification and characterization of putative neuronal nicotinic acetylcholine receptor subtypes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)48297-x ◽

1987 ◽

Vol 262 (14) ◽

pp. 6691-6698 ◽

Cited By ~ 1

Author(s):

J M Henley ◽

R E Oswald

Keyword(s):

Acetylcholine Receptor ◽

Binding Sites ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Subtypes ◽

Nicotinic Acetylcholine ◽

Identification and characterization of membrane-associated polypeptides in Torpedo nicotinic acetylcholine receptor-rich membranes by hydrophobic photolabeling

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/s0005-2736(01)00321-2 ◽

2001 ◽

Vol 1512 (2) ◽

pp. 215-224 ◽

Cited By ~ 10

Author(s):

Michael P. Blanton ◽

Anil K. Lala ◽

Jonathan B. Cohen

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

Journal of Medicinal Chemistry ◽

10.1021/jm300247y ◽

2012 ◽

Vol 55 (10) ◽

pp. 4806-4823 ◽

Cited By ~ 21

Author(s):

Riccardo Zanaletti ◽

Laura Bettinetti ◽

Cristiana Castaldo ◽

Giuseppe Cocconcelli ◽

Thomas Comery ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Pentanoic Acid ◽

Nicotinic Acetylcholine ◽

Alpha 7

Identification and Characterization of a 47 Base Pair Activity-Dependent Enhancer of the Rat Nicotinic Acetylcholine Receptor δ-Subunit Promoter

Journal of Neuroscience ◽

10.1523/jneurosci.16-11-03641.1996 ◽

1996 ◽

Vol 16 (11) ◽

pp. 3641-3651 ◽

Cited By ~ 27

Author(s):

Wade Walke ◽

Guozhi Xiao ◽

Daniel Goldman

Keyword(s):

Acetylcholine Receptor ◽

Base Pair ◽

Nicotinic Acetylcholine ◽

Activity Dependent ◽

Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor

Biochemical Pharmacology ◽

10.1016/j.bcp.2020.114010 ◽

2020 ◽

Vol 177 ◽

pp. 114010

Author(s):

Monika Cieslikiewicz-Bouet ◽

Marina Naldi ◽

Manuela Bartolini ◽

Belén Pérez ◽

Denis Servent ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Functional Characterization ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Multifunctional Ligands