Nonpeptide Angiotensin II Receptor Antagonists:  Synthesis, Biological Activities, and Structure−Activity Relationships of Imidazole-5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds

Hiroaki Yanagisawa; Yoshiya Amemiya; Takuro Kanazaki; Yasuo Shimoji; Koichi Fujimoto; Yoshiko Kitahara; Toshio Sada; Makoto Mizuno; Masahiro Ikeda; Shuichi Miyamoto; Youji Furukawa; Hiroyuki Koike

doi:10.1021/jm950450f

Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activities, and Structure−Activity Relationships of Imidazole-5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds

Journal of Medicinal Chemistry ◽

10.1021/jm950450f ◽

1996 ◽

Vol 39 (1) ◽

pp. 323-338 ◽

Cited By ~ 96

Author(s):

Hiroaki Yanagisawa ◽

Yoshiya Amemiya ◽

Takuro Kanazaki ◽

Yasuo Shimoji ◽

Koichi Fujimoto ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acids ◽

Biological Activities ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Related Compounds

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Cited By ~ 9

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00061a016 ◽

1993 ◽

Vol 36 (9) ◽

pp. 1245-1254 ◽

Cited By ~ 36

Author(s):

Robert H. Bradbury ◽

Christopher P. Allott ◽

Michael Dennis ◽

J. Alan Girdwood ◽

Peter W. Kenny ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Properties ◽

Pyridine Derivatives ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00077a007 ◽

1993 ◽

Vol 36 (25) ◽

pp. 4040-4051 ◽

Cited By ~ 130

Author(s):

Uwe J. Ries ◽

Gerhard Mihm ◽

Berthold Narr ◽

Kai M. Hasselbach ◽

Helmut Wittneben ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00068a010 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2335-2342 ◽

Cited By ~ 59

Author(s):

Kyoung Soon Kim ◽

Ligang Qian ◽

J. Eileen Bird ◽

Kenneth E. J. Dickinson ◽

Suzanne Moreland ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Properties ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

ChemInform Abstract: New Nonpeptide Angiotensin II Receptor Antagonists. Part 2. Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Alkyl- 4-(biphenylylmethoxy)quinoline Derivatives.

ChemInform ◽

10.1002/chin.199321171 ◽

2010 ◽

Vol 24 (21) ◽

pp. no-no

Author(s):

R. H. BRADBURY ◽

C. P. ALLOTT ◽

M. DENNIS ◽

E. FISHER ◽

J. S. MAJOR ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Properties ◽

Quinoline Derivatives ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

ChemInform Abstract: Nonpeptide Angiotensin II Receptor Antagonists. Part 2. Design, Synthesis, and Structure-Activity Relationships of 2-Alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole Derivatives: Profile of 2-Propyl-1-((2′-(1H-tetrazol-5-yl)-(1,1′-biphenyl)-4-yl

ChemInform ◽

10.1002/chin.199352180 ◽

2010 ◽

Vol 24 (52) ◽

pp. no-no

Author(s):

I. SIRCAR ◽

J. C. HODGES ◽

J. III QUIN ◽

A. M. BUNKER ◽

R. T. WINTERS ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm00100a007 ◽

1992 ◽

Vol 35 (22) ◽

pp. 4027-4038 ◽

Cited By ~ 42

Author(s):

Robert H. Bradbury ◽

Christopher P. Allott ◽

Michael Dennis ◽

Eric Fisher ◽

John S. Major ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Properties ◽

Quinoline Derivatives ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin II receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(97)00026-7 ◽

1997 ◽

Vol 7 (4) ◽

pp. 385-388 ◽

Cited By ~ 9

Author(s):

Terukage Hirata ◽

Satoru Goto ◽

Koichi Tamura ◽

Masayasu Okuhira ◽

Yoshimitsu Nagao

Keyword(s):

Angiotensin Ii ◽

Quantitative Structure ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

New non-peptide angiotensin II receptor antagonists. 1: structure - activity relationships of a series of a series of 2(1H)-pyridinones.

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)81133-1 ◽

1994 ◽

Vol 4 (1) ◽

pp. 121-126 ◽

Cited By ~ 7

Author(s):

John R. Bantick ◽

Haydn G. Beaton ◽

Sally L. Cooper ◽

Stephen Hill ◽

Simon C. Hirst ◽

...

Keyword(s):

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

ChemInform Abstract: Quinoxaline N-Oxide Containing Potent Angiotensin II Receptor Antagonists: Synthesis, Biological Properties, and Structure-Activity Relationships.

ChemInform ◽

10.1002/chin.199352202 ◽

2010 ◽

Vol 24 (52) ◽

pp. no-no

Author(s):

K. S. KIM ◽

L. QIAN ◽

J. E. BIRD ◽

K. E. J. DICKINSON ◽

S. MORELAND ◽

...

Keyword(s):

Angiotensin Ii ◽

Biological Properties ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity