Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

James M. Hamby; Cleo J. C. Connolly; Mel C. Schroeder; R. Thomas Winters; H. D. Hollis Showalter; Robert L. Panek; Terry C. Major; Bronislawa Olsewski; Michael J. Ryan; Tawny Dahring; Gina H. Lu; Joan Keiser; Aneesa Amar; Cindy Shen; Alan J. Kraker; Veronika Slintak; James M. Nelson; David W. Fry; Laura Bradford; Hussein Hallak; Annette M. Doherty

doi:10.1021/jm970367n

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm970367n ◽

1997 ◽

Vol 40 (15) ◽

pp. 2296-2303 ◽

Cited By ~ 85

Author(s):

James M. Hamby ◽

Cleo J. C. Connolly ◽

Mel C. Schroeder ◽

R. Thomas Winters ◽

H. D. Hollis Showalter ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

Synthesis and Structure−Activity Relationships of Linear and Conformationally Constrained Peptide Analogues of CIYKYY as Src Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm060334k ◽

2006 ◽

Vol 49 (11) ◽

pp. 3395-3401 ◽

Cited By ~ 13

Author(s):

Anil Kumar ◽

Guofeng Ye ◽

Yuehao Wang ◽

Xiaofeng Lin ◽

Gongqin Sun ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Src Tyrosine Kinase ◽

Conformationally Constrained ◽

Structure Activity Relationships ◽

Structure Activity ◽

Peptide Analogues

Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors

Oncology Reports ◽

10.3892/or.2018.6542 ◽

2018 ◽

Cited By ~ 4

Author(s):

Shuang Lai ◽

Jun‑Ning Chen ◽

Han‑Wei Huang ◽

Xiang‑Yu Zhang ◽

Hai‑Lun Jiang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 5. Synthesis and Structure-Activity Relationships for 4-((Phenylmethyl)amino)- and 4-(Phenylamino) quinazolines as Potent Adenosine 5′-Triphosphate Binding Site Inhibitors of the Tyrosine Kinase Domain

ChemInform ◽

10.1002/chin.199552154 ◽

2010 ◽

Vol 26 (52) ◽

pp. no-no

Author(s):

G. W. REWCASTLE ◽

W. A. DENNY ◽

A. J. BRIDGES ◽

H. ZHOU ◽

D. R. CODY ◽

...

Keyword(s):

Tyrosine Kinase ◽

Binding Site ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Kinase Domain ◽

Tyrosine Kinase Domain ◽

Structure Activity Relationships ◽

Structure Activity

Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm960879m ◽

1997 ◽

Vol 40 (12) ◽

pp. 1820-1826 ◽

Cited By ~ 66

Author(s):

Gordon W. Rewcastle ◽

Alexander J. Bridges ◽

David W. Fry ◽

J. Ronald Rubin ◽

William A. Denny

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Epidermal Growth

Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities ofN-Phenyl-N‘-{4-(4-quinolyloxy)phenyl}ureas

Journal of Medicinal Chemistry ◽

10.1021/jm030427r ◽

2005 ◽

Vol 48 (5) ◽

pp. 1359-1366 ◽

Cited By ~ 101

Author(s):

Kazuo Kubo ◽

Toshiyuki Shimizu ◽

Shin-ichi Ohyama ◽

Hideko Murooka ◽

Akemi Iwai ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Antitumor Activities ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm101036c ◽

2010 ◽

Vol 53 (22) ◽

pp. 8140-8149 ◽

Cited By ~ 33

Author(s):

Peng Cho Tang ◽

Yi Dong Su ◽

Jun Feng ◽

Jian Hong Fu ◽

Jiang Liang Yang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Antitumor Activities ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases

Journal of Medicinal Chemistry ◽

10.1021/jm00001a011 ◽

1995 ◽

Vol 38 (1) ◽

pp. 58-67 ◽

Cited By ~ 47

Author(s):

Brian D. Palmer ◽

Gordon W. Rewcastle ◽

Andrew M. Thompson ◽

Maruta Boyd ◽

H. D. Hollis Showalter ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Structure Activity Relationships ◽

Structure Activity ◽

In Vitro Inhibition ◽

Nonreceptor Protein Tyrosine Kinases

Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships amongN- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparativein Vitroandin VivoStudies against Selected Sulfur Congeners

Journal of Medicinal Chemistry ◽

10.1021/jm960689b ◽

1997 ◽

Vol 40 (4) ◽

pp. 413-426 ◽

Cited By ~ 44

Author(s):

H. D. Hollis Showalter ◽

Anthony D. Sercel ◽

Boguslawa M. Leja ◽

Craig D. Wolfangel ◽

Linda A. Ambroso ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Protein Tyrosine ◽

Structure Activity Relationships ◽

Structure Activity

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2′-Dithiobis(1-methyl-N-phenyl-1H-indole-3- carboxamide).

ChemInform ◽

10.1002/chin.199450135 ◽

2010 ◽

Vol 25 (50) ◽

pp. no-no

Author(s):

G. W. REWCASTLE ◽

B. D. PALMER ◽

E. M. DOBRUSIN ◽

D. W. FRY ◽

A. J. KRAKER ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Protein Tyrosine ◽

Structure Activity Relationships ◽

Structure Activity ◽

Derivatives Of

Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)

Journal of Medicinal Chemistry ◽

10.1021/jm00039a016 ◽

1994 ◽

Vol 37 (13) ◽

pp. 2033-2042 ◽

Cited By ~ 22

Author(s):

Gordon W. Rewcastle ◽

Brian D. Palmer ◽

Ellen M. Dobrusin ◽

David W. Fry ◽

Alan J. Kraker ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Tyrosine Kinases ◽

Kinase Inhibitors ◽

Protein Tyrosine Kinases ◽

Protein Tyrosine ◽

Structure Activity Relationships ◽

Structure Activity ◽

Derivatives Of