Photochemical and Thermal Ring-Contraction of Cyclic Hydroxamic Acid Derivatives

2012 ◽  
Vol 77 (24) ◽  
pp. 11216-11226 ◽  
Author(s):  
Simon Pichette ◽  
Samuel Aubert-Nicol ◽  
Jean Lessard ◽  
Claude Spino
Keyword(s):  
Hydroxamic Acid ◽  
Ring Contraction ◽  
Cyclic Hydroxamic Acid ◽  
Hydroxamic Acid Derivatives

Synthesis of Cyclic Hydroxamic Acid Derivatives of Pyrazine

1952 ◽  
Vol 17 (10) ◽  
pp. 1298-1301 ◽  
Author(s):  
S. R. Safir ◽  
J. H. Williams
Keyword(s):  
Hydroxamic Acid ◽  
Derivatives Of ◽  
Cyclic Hydroxamic Acid ◽  
Hydroxamic Acid Derivatives

Reactions of Nitrosobenzenes with Cyclobutanones by Activation with a Lewis Acid

Synlett ◽  
2017 ◽  
Vol 29 (06) ◽  
pp. 723-726 ◽  
Author(s):  
Jun-ichi Matsuo ◽  
Yusuke Shima ◽  
Emiko Igarashi ◽  
Tomoyuki Yoshimura
Keyword(s):  
Lewis Acid ◽  
Hydroxamic Acid ◽  
The Other ◽  
Other Hand ◽  
Cyclic Hydroxamic Acid ◽  
Hydroxamic Acid Derivatives

Formal [4+2] cycloaddition between 3-ethoxy-2-alkylcyclobutanones and nitrosobenzene proceeded by activation with Me3SiOTf to afford 6-alkyl-2-phenyl-2H-1,2-oxazin-5(6H)-one by regioselective cleavage of the more substituted C2–C3 bond of the cyclobutanone ring. On the other hand, reactions of 3-phenylcyclobutanones and 2-benzyloxycyclobutanone with nitrosobenzene gave γ,δ-unsaturated and cyclic hydroxamic acid derivatives, respectively, by cleavage of a cyclobutanone C1–C2 bond.

ChemInform Abstract: Syntheses of Cyclic Hydroxamic Acid Derivatives, and Their Chelating Abilities and Biological Activities.

ChemInform ◽  
1989 ◽  
Vol 20 (6) ◽  
Author(s):  
K. TANAKA ◽  
K. MATSUO ◽  
A. NAKANISHI ◽  
Y. KATAOKA ◽  
K. TAKASE ◽  
...  
Keyword(s):  
Hydroxamic Acid ◽  
Biological Activities ◽  
Cyclic Hydroxamic Acid ◽  
Hydroxamic Acid Derivatives

scholarly journals Syntheses of cyclic hydroxamic acid derivatives, and their chelating abilities and biological activities.

1988 ◽  
Vol 36 (7) ◽  
pp. 2323-2330 ◽  
Author(s):  
KUNIYOSHI TANAKA ◽  
KEIZO MATUSO ◽  
AI NAKANISHI ◽  
YOSUKE KATAOKA ◽  
KAZUKO TAKASE ◽  
...  
Keyword(s):  
Hydroxamic Acid ◽  
Biological Activities ◽  
Cyclic Hydroxamic Acid ◽  
Hydroxamic Acid Derivatives

scholarly journals Cross metathesis-mediated synthesis of hydroxamic acid derivatives

2018 ◽  
Vol 14 ◽  
pp. 3070-3075 ◽  
Author(s):  
Shital Kumar Chattopadhyay ◽  
Subhankar Ghosh ◽  
Suman Sil
Keyword(s):  
Hydroxamic Acid ◽  
Cyclic Peptide ◽  
Alternative Synthesis ◽  
Acid Component ◽  
Cross Metathesis ◽  
Reaction Proceeds ◽  
Amino Acid Component ◽  
Short Time ◽  
Unusual Amino Acid ◽  
Hydroxamic Acid Derivatives

An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N-benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good yields (57–85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70–89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.

The Effect of Gabapentin-Lactam Hydroxamic Acid Derivatives on Ovine Osteoblast Proliferation and Phenotype: Perspectives for Tissue Engineering Application

2014 ◽  
Vol 29 (1) ◽  
pp. e73-e80
Author(s):  
Fabian Duttenhoefer ◽  
Marc Anton Fuessinger ◽  
Sieglinde Ahne ◽  
Toshiyuki Oshima ◽  
Ralf Gutwald ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hydroxamic Acid ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Osteoblast Proliferation ◽  
Hydroxamic Acid Derivatives

Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy

2017 ◽  
Vol 25 (15) ◽  
pp. 4100-4109 ◽  
Author(s):  
Zigao Yuan ◽  
Shaopeng Chen ◽  
Qinsheng Sun ◽  
Ning Wang ◽  
Dan Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Hydroxamic Acid ◽  
Hdac Inhibitors ◽  
Hydroxamic Acid Derivatives

Design, Synthesis, and Biological Evaluation of Pyrazoline-Based Hydroxamic Acid Derivatives as Aminopeptidase N (APN) Inhibitors

ChemMedChem ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. 431-436 ◽  
Author(s):  
Jiangying Cao ◽  
Jie Zang ◽  
Chunhua Ma ◽  
Xiaoguang Li ◽  
Jinning Hou ◽  
...  
Keyword(s):  
Hydroxamic Acid ◽  
Biological Evaluation ◽  
Aminopeptidase N ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hydroxamic Acid Derivatives

Hydroxamic acid derivatives as histone deacetylase inhibitors: a DFT study of their tautomerism and metal affinities/selectivities

2018 ◽  
Vol 24 (5) ◽  
Author(s):  
D. Cheshmedzhieva ◽  
N. Toshev ◽  
M. Gerova ◽  
O. Petrov ◽  
T. Dudev
Keyword(s):  
Histone Deacetylase ◽  
Hydroxamic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Dft Study ◽  
Hydroxamic Acid Derivatives
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