NMRP versus “Click” Chemistry for the Synthesis of Semiconductor Polymers Carrying Pendant Perylene Bisimides

Andreas S. Lang; Anne Neubig; Michael Sommer; Mukundan Thelakkat

doi:10.1021/ma100708h

NMRP versus “Click” Chemistry for the Synthesis of Semiconductor Polymers Carrying Pendant Perylene Bisimides

Macromolecules ◽

10.1021/ma100708h ◽

2010 ◽

Vol 43 (17) ◽

pp. 7001-7010 ◽

Cited By ~ 40

Author(s):

Andreas S. Lang ◽

Anne Neubig ◽

Michael Sommer ◽

Mukundan Thelakkat

Keyword(s):

Click Chemistry ◽

Perylene Bisimides

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Modular synthesis of poly(perylene bisimides) using click chemistry: a comparative study

Polymer Chemistry ◽

10.1039/c1py00191d ◽

2011 ◽

Vol 2 (10) ◽

pp. 2213 ◽

Cited By ~ 19

Author(s):

Andreas S. Lang ◽

Mukundan Thelakkat

Keyword(s):

Comparative Study ◽

Click Chemistry ◽

Modular Synthesis ◽

Perylene Bisimides

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New click chemistry reaction: sulfur fluoride exchange

AccessScience ◽

10.1036/1097-8542.br0902141 ◽

2015 ◽

Keyword(s):

Click Chemistry ◽

Sulfur Fluoride

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Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

10.26434/chemrxiv.10314647.v1 ◽

2019 ◽

Cited By ~ 1

Author(s):

Qinheng Zheng ◽

Hongtao Xu ◽

Hua Wang ◽

Wen-Ge Han Du ◽

Nan Wang ◽

...

Keyword(s):

Click Chemistry ◽

High Performance ◽

Isotopic Exchange ◽

Tumor Imaging ◽

Radiochemical Yield ◽

Exchange Method ◽

Molar Activity ◽

Positron Emission ◽

Sulfur Fluoride

The lack of simple, efficient [18F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [18F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated 18F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol–1) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [18F]fluorosulfate is demonstrated by the in vivo tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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