Facile Synthesis of Peptidyl Salicylaldehyde Esters and Its Use in Cyclic Peptide Synthesis

2013 ◽  
Vol 15 (20) ◽  
pp. 5182-5185 ◽  
Author(s):  
Jun-Feng Zhao ◽  
Xiao-Hong Zhang ◽  
Ying-Jie Ding ◽  
Yong-Sheng Yang ◽  
Xiao-Bao Bi ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Facile Synthesis ◽  
Cyclic Peptide Synthesis

Cyclic Peptide Synthesis with Thioacids

2010 ◽  
Vol 12 (14) ◽  
pp. 3254-3257 ◽  
Author(s):  
Kaname Sasaki ◽  
David Crich
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

scholarly journals Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

2018 ◽  
Vol 14 ◽  
pp. 1112-1119 ◽  
Author(s):  
Dan Liu ◽  
Ya-Li Guo ◽  
Jin Qu ◽  
Chi Zhang
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Solid Phase ◽  
Biological Activities ◽  
Solid Phase Peptide Synthesis ◽  
Coupling Reaction ◽  
Hypervalent Iodine ◽  
Peptide Coupling ◽  
Cyclic Peptide Synthesis ◽  
Cyclic Heptapeptide

The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.

scholarly journals Chlorofusin Cyclic Peptide Synthesis

Synfacts ◽  
2020 ◽  
Vol 16 (03) ◽  
pp. 0363
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

Utilizing Copper-Mediated Deprotection of Selenazolidine for Cyclic Peptide Synthesis

2019 ◽  
Vol 85 (3) ◽  
pp. 1731-1739 ◽  
Author(s):  
Zhenguang Zhao ◽  
Norman Metanis
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

Disulfide-Driven Cyclic Peptide Synthesis of Human Endothelin-2 with a Solid-Supported Npys-Cl

2019 ◽  
Vol 85 (3) ◽  
pp. 1495-1503 ◽  
Author(s):  
Akihiro Taguchi ◽  
Kiyotaka Kobayashi ◽  
Yan Cui ◽  
Kentaro Takayama ◽  
Atsuhiko Taniguchi ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

Cyclic Peptide Synthesis Using Peptidyl Salicylaldehyde Esters

Synfacts ◽  
2013 ◽  
Vol 10 (01) ◽  
pp. 0105-0105
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

Development of a solid-phase traceless-Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

2018 ◽  
Vol 111 (1) ◽  
pp. e24044 ◽  
Author(s):  
Steve Jobin ◽  
Catherine Beaumont ◽  
Eric Biron
Keyword(s):  
Peptide Synthesis ◽  
Multicomponent Reaction ◽  
Cyclic Peptide ◽  
Solid Phase ◽  
Cyclic Peptide Synthesis

Complex cyclic peptide synthesis via serine/threonine ligation chemistry

2021 ◽  
pp. 128430
Author(s):  
Jinzheng Wang ◽  
Xuechen Li
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Cyclic Peptide Synthesis

Extended Solution-phase Peptide Synthesis Strategy Using Isostearyl-Mixed Anhydride Coupling and a New C-Terminal Silyl Ester-Protecting Group for N-Methylated Cyclic Peptide Production

2021 ◽  
Vol 25 (9) ◽  
pp. 2029-2038
Author(s):  
Akihiro Nagaya ◽  
Shota Murase ◽  
Yuji Mimori ◽  
Kazuya Wakui ◽  
Madoka Yoshino ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Solution Phase ◽  
Protecting Group ◽  
Mixed Anhydride ◽  
Silyl Ester ◽  
Synthesis Strategy

scholarly journals Pyrrole-Mediated Peptide Cyclization Identified through Genetically Reprogrammed Peptide Synthesis

Biomedicines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 99 ◽  
Author(s):  
Klaas Decoene ◽  
Willem Vannecke ◽  
Toby Passioura ◽  
Hiroaki Suga ◽  
Annemieke Madder
Keyword(s):  
Peptide Synthesis ◽  
Cyclic Peptide ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Screening Method ◽  
In Vitro Translation ◽  
Side Chain ◽  
One Pot ◽  
Depth Analysis

Flexible in vitro translation (FIT) was used as a screening method to uncover a new methodology for peptide constraining based on the attack of a nucleophilic side-chain functionality onto an oxidized furylalanine side chain. A set of template peptides, each containing furylalanine as furan-modified amino acid and a nucleophilic residue (Cys, His, Lys, Arg, Ser, or Tyr), was produced through FIT. The translation mixtures were treated with N-bromosuccinimide (NBS) to achieve selective furan oxidation and subsequent MALDI analysis demonstrated Lys and Ser as promising residues for cyclisation. Solid-phase peptide synthesis (SPPS) was used to synthesize suitable amounts of material for further in-depth analysis and characterisation. It was found that in the case of the peptide containing lysine next to a furylalanine residue, a one-pot oxidation and reduction reaction leads to the generation of a cyclic peptide featuring a pyrrole moiety as cyclisation motif, resulting from the attack of the lysine side chain onto the oxidized furylalanine side chain. Structural evidence was provided via NMR and the generality of the methodology was explored. We hereby expand the scope of our previously developed furan-based peptide labeling and crosslinking strategy.

Sign in / Sign up

Export Citation Format

Share Document