Alkylation of Rhodium Porphyrins Using Ammonium and Quinolinium Salts

2014 ◽  
Vol 33 (14) ◽  
pp. 3757-3767 ◽  
Author(s):  
Samuel J. Thompson ◽  
Guangbin Dong
Keyword(s):  
Rhodium Porphyrins ◽  
Quinolinium Salts

Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

2020 ◽  
Vol 23 (21) ◽  
pp. 2271-2294 ◽  
Author(s):  
Divya Utreja ◽  
Shivali Sharma ◽  
Akhil Goyal ◽  
Komalpreet Kaur ◽  
Sonia Kaushal
Keyword(s):  
Tyrosine Kinases ◽  
Biological Activities ◽  
Polymeric Materials ◽  
Tubulin Polymerization ◽  
Quinoline Derivatives ◽  
Heterocyclic Chemistry ◽  
Biological Profile ◽  
Drug Candidates ◽  
Anti Hiv ◽  
Quinolinium Salts

Heterocyclic chemistry is the only branch of chemistry that has applications in varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials, biological, and many other fields. Quinoline and its derivatives have always engrossed both synthetic chemists and biologists because of their diverse chemical and pharmacological properties as these ring systems can be easily found in various natural products, especially in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have attracted much attention nowadays owing to their diverse biological profile such as antimicrobial, antitumor, antifungal, hypotensive, anti-HIV, analgesics and anti-inflammatory, etc. Quinoline and its analogs have recently been examined for their modes of function in the inhibition of tyrosine kinases, proteasome, tubulin polymerization, topoisomerase, and DNA repair. These observations have been guiding scientists for the expansion of new quinoline derivatives with improved and varied biological activities. Quinolinium salts have immense possibilities and scope to investigate these compounds as potential drug candidates. Therefore, we shall present a concise compilation of this work to aid in present knowledge and to help researchers explore an interesting quinoline class having medicinal potential.

Relationship between structure and inhibition behaviour of quinolinium salts for mild steel corrosion: Experimental and theoretical approach

2015 ◽  
Vol 95 ◽  
pp. 71-87 ◽  
Author(s):  
Punita Mourya ◽  
Praveen Singh ◽  
A.K. Tewari ◽  
R.B. Rastogi ◽  
M.M. Singh
Keyword(s):  
Mild Steel ◽  
Theoretical Approach ◽  
Steel Corrosion ◽  
Mild Steel Corrosion ◽  
Quinolinium Salts

THE CONVERSION OF LILOLINE DERIVATIVES TO QUINOLINIUM SALTS USING CYANOGEN BROMIDE

1954 ◽  
Vol 19 (4) ◽  
pp. 504-509 ◽  
Author(s):  
V. BOEKELHEIDE ◽  
WALTER G. GALL
Keyword(s):  
Cyanogen Bromide ◽  
Quinolinium Salts

scholarly journals Toxicity and Apoptosis Related Effects of Benzimidazo [3,2-α] Quinolinium Salts Upon Human Lymphoma Cells

2017 ◽  
Vol 11 (1) ◽  
pp. 54-65 ◽  
Author(s):  
Christian Vélez ◽  
Jessica Soto ◽  
Karoline Ríos ◽  
Luz Silva ◽  
Wigberto Hernandez ◽  
...  
Keyword(s):  
Ros Generation ◽  
Fluorescence Staining ◽  
Cycle Arrest ◽  
Effector Caspase ◽  
Anti Cancer ◽  
Independent Mechanism ◽  
Human Lymphoma ◽  
Apoptosis Inducing Factor ◽  
Related Proteins ◽  
Quinolinium Salts

Objectives: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2-a]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to known anti-cancer substances such as ellipticine and berberine. Methods: Toledo human lymphoma (ATCC CRL2631) cells were treated for 24 to 48 hours. Apoptosis related endpoints such as cell cycle arrest, mitochondrial damage, RNS and ROS generation and the activity of several apoptosis related proteins such as caspases and apoptosis inducing factor (AIF) were studied using fluorescence staining and western blot respectively. Results: Results indicated a higher toxicity from the amino substituted ABQ-48 versus the NBQ-48 (GI50’s of 50uM versus 100uM respectively). Both compounds induced cell death through various apoptosis related endpoints including a decrease in mitochondrial membrane potential with an increase in ROS and activation of the effector caspase 3. Interestingly, AIF release was observed on cells treated with the amino substituted ABQ-48 but not on the nitro substituted NBQ-48 samples suggesting a caspase independent mechanism for ABQ-48. Conclusions: The results obtained presents the toxic effects of two novel benzimidazo[3,2-a]quinolinium salts in human lymphoma tumor cells. The identified mechanism of action includes multiple apoptosis related effects. Furthermore the data presents a clear variation in caspase dependent or independent mechanism for each compound.

Benzo[f]quinolinium salts: antibacterial and antifungal activities

2021 ◽  
Author(s):  
Vasilichia Antoci ◽  
Gheorghita Zbancioc ◽  
Liliana Oniciuc ◽  
Dorina Amariucai-Mantu ◽  
Costel Moldoveanu ◽  
...  
Keyword(s):  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Quinolinium Salts

Antimicrobial activity of quaternary 4-(p-dimethylaminostyryl)quinolinium salts

1984 ◽  
Vol 18 (8) ◽  
pp. 561-563
Author(s):  
V. I. Voznyak ◽  
L. G. Savitskaya ◽  
D. D. Neporadnyi
Keyword(s):  
Antimicrobial Activity ◽  
Quinolinium Salts

Abstract 1586: Toxicity screening, apoptosis hallmark events and nitro reduction of novel quinolinium salts (BQS) on lymphoma cells

2014 ◽  
Author(s):  
Karoline Rios-Rodriguez ◽  
Jessica Soto ◽  
Christian Velez ◽  
Osvaldo Cox ◽  
Juan P. Rivera ◽  
...  
Keyword(s):  
Toxicity Screening ◽  
Lymphoma Cells ◽  
Nitro Reduction ◽  
Quinolinium Salts

ChemInform Abstract: HETEROCYCLIC STUDIES. XXXVIII. SYNTHESIS AND DISPROPORTIONATION OF PYRIMIDO(4,5-B)QUINOLINIUM SALTS

1976 ◽  
Vol 7 (16) ◽  
pp. no-no
Author(s):  
JIM CLARK ◽  
BAHMAN PARVIZI
Keyword(s):  
Quinolinium Salts
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