Theoretical Studies of the Mechanism of N-Hydroxylation of Primary Aromatic Amines by Cytochrome P450 1A2: Radicaloid or Anionic?

Chemical Research in Toxicology ◽

10.1021/tx400376u ◽

2014 ◽

Vol 27 (2) ◽

pp. 265-278 ◽

Author(s):

Lena Ripa ◽

Christine Mee ◽

Peter Sjö ◽

Igor Shamovsky

Keyword(s):

Cytochrome P450 ◽

Aromatic Amines ◽

Theoretical Studies ◽

Cytochrome P450 1A2 ◽

Primary Aromatic Amines

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Model and Mechanism: N-Hydroxylation of Primary Aromatic Amines by Cytochrome P450

Angewandte Chemie International Edition ◽

10.1002/anie.201204116 ◽

2012 ◽

Vol 52 (2) ◽

pp. 744-748 ◽

Author(s):

Li Ji ◽

Gerrit Schüürmann

Keyword(s):

Cytochrome P450 ◽

Aromatic Amines ◽

Primary Aromatic Amines

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Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.5b00177 ◽

2015 ◽

Vol 28 (8) ◽

pp. 1603-1615 ◽

Author(s):

Robert J. Turesky ◽

Kami K. White ◽

Lynne R. Wilkens ◽

Loïc Le Marchand

Keyword(s):

Cytochrome P450 ◽

Aromatic Amines ◽

Heterocyclic Aromatic Amines ◽

Metabolic Phenotype ◽

Cytochrome P450 1A2

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Influence of cytochrome P450 mixed-function oxidase induction on the acute toxicity to rainbow trout (Salmo gairdneri) of primary aromatic amines

Ecotoxicology and Environmental Safety ◽

10.1016/0147-6513(90)90054-9 ◽

1990 ◽

Vol 20 (2) ◽

pp. 156-166 ◽

Author(s):

Joop L.M. Hermens ◽

Steven P. Bradbury ◽

Steven J. Broderius

Keyword(s):

Cytochrome P450 ◽

Rainbow Trout ◽

Acute Toxicity ◽

Aromatic Amines ◽

Salmo Gairdneri ◽

Mixed Function Oxidase ◽

Primary Aromatic Amines

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Heterologous Co-Expression of Human Cytochrome P450 1A2 and Polymorphic Forms of N-Acetyltransferase 2 for Studies on Aromatic Amines in V79 Chinese Hamster Cells

Alternatives to Laboratory Animals ◽

10.1177/026119290503300609 ◽

2005 ◽

Vol 33 (6) ◽

pp. 561-577 ◽

Author(s):

Jürgen Scheuenpflug ◽

Niels Krebsfänger ◽

Johannes Doehmer

Keyword(s):

Cytochrome P450 ◽

Aromatic Amines ◽

Chinese Hamster ◽

Cytochrome P450 1A2 ◽

Chinese Hamster Cells ◽

Human Cytochrome ◽

Polymorphic Forms

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Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/s0027-5107(99)00120-7 ◽

1999 ◽

Vol 429 (2) ◽

pp. 199-208 ◽

Author(s):

P.David Josephy ◽

David H Evans ◽

Vanessa Williamson ◽

Tracey Henry ◽

F.Peter Guengerich

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Aromatic Amines ◽

Coli Strain ◽

Cytochrome P450 1A2 ◽

Human Cytochrome

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Activation of Heterocyclic Aromatic Amines by Rat and Human Liver Microsomes and by Purified Rat and Human Cytochrome P450 1A2†

Chemical Research in Toxicology ◽

10.1021/tx980022n ◽

1998 ◽

Vol 11 (8) ◽

pp. 925-936 ◽

Author(s):

Robert J. Turesky ◽

Anne Constable ◽

Janique Richoz ◽

Nathalia Varga ◽

Jovanka Markovic ◽

...

Keyword(s):

Cytochrome P450 ◽

Aromatic Amines ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Heterocyclic Aromatic Amines ◽

Cytochrome P450 1A2 ◽

Human Cytochrome

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Study to Characterize the Effects of Cytochrome p450 1A2 Inhibition on Systemic Exposure to BMS-986165

Case Medical Research ◽

10.31525/ct1-nct03930602 ◽

2019 ◽

Author(s):

Keyword(s):

Cytochrome P450 ◽

Systemic Exposure ◽

Cytochrome P450 1A2

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A Study to Investigate the Effects of Cytochrome P450 1A2 Induction by Ritonavir on BMS-986165 Drug Levels and Effects in Healthy Participants

Case Medical Research ◽

10.31525/ct1-nct04055506 ◽

2019 ◽

Author(s):

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 1A2 ◽

Drug Levels ◽

Healthy Participants

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Faculty Opinions recommendation of Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13294018.793462117 ◽

2012 ◽

Author(s):

Steve Young

Keyword(s):

Aromatic Amines ◽

Theoretical Studies ◽

Activation Pathways

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Faculty Opinions recommendation of Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727175594.793531265 ◽

2017 ◽

Author(s):

Ayyalusamy Ramamoorthy

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 1A2

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