Influence of cytochrome P450 mixed-function oxidase induction on the acute toxicity to rainbow trout (Salmo gairdneri) of primary aromatic amines

1990 ◽  
Vol 20 (2) ◽  
pp. 156-166 ◽  
Author(s):  
Joop L.M. Hermens ◽  
Steven P. Bradbury ◽  
Steven J. Broderius
Keyword(s):  
Cytochrome P450 ◽  
Rainbow Trout ◽  
Acute Toxicity ◽  
Aromatic Amines ◽  
Salmo Gairdneri ◽  
Mixed Function Oxidase ◽  
Primary Aromatic Amines

Assessment of the Acute Toxicity, Growth Impairment, and Flesh Tainting Potential of a Bleached Kraft Mill Effluent on Rainbow Trout (Salmo gairdneri)

1977 ◽  
Vol 34 (6) ◽  
pp. 869-878 ◽  
Author(s):  
D. M. Whittle ◽  
K. W. Flood
Keyword(s):  
Rainbow Trout ◽  
Acute Toxicity ◽  
Continuous Flow ◽  
Effluent Treatment ◽  
Salmo Gairdneri ◽  
Freshwater Ecosystem ◽  
Juvenile Rainbow Trout ◽  
Effluent Concentration ◽  
Kraft Mill Effluent ◽  
Kraft Mill

Static and continuous-flow bioassays utilizing juvenile rainbow trout (Salmo gairdneri) were conducted on a northern Ontario bleached kraft mill effluent to assess the range of acute toxicity and related sublethal effects. The acute toxicity of the total mill effluent, as determined by static bioassay procedures, ranged from a 96-h LC50 value of 14–49.0% vol/vol. The results of these bioassays depended on testing methodology and effluent treatment systems employed by the mill when samples were collected. Continuous-flow bioassays conducted on the effluent Produced 96-h LC50 values of 21.8 and 24.8% vol/vol. Growth rate of juvenile rainbow trout (1–2 g) held under continuous-flow conditions for 18 days was significantly reduced at 6% vol/vol effluent concentration (P < 0.05). Flavor of yearling rainbow trout [Formula: see text] exposed to 3% effluent for 48 h was significantly impaired (P < 0.05). This effluent concentration, the lowest level impairing flavor represents approximately 0.12 of the 96-h LC50 derived from continuous-flow bioassays. No significant flavor impairment was detected in fish exposed for 144 h to a 2% effluent concentration Flavor impairment at a 3% vol/vol effluent concentration, the most sensitive sublethal response measured in this study, may also be the most critical response when assessing the economic impact of a kraft mill discharge to a freshwater ecosystem.

Acute toxicity of aflatoxins B1 and G1 in the rainbow trout (Salmo gairdneri)

1969 ◽  
Vol 15 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Diana H. Bauer ◽  
Donald J. Lee ◽  
Russell O. Sinnhuber
Keyword(s):  
Rainbow Trout ◽  
Acute Toxicity ◽  
Salmo Gairdneri

Turnover and Urinary Excretion of Free and Acetylated M.S. 222 by Rainbow Trout, Salmo gairdneri

1968 ◽  
Vol 25 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Joseph B. Hunn ◽  
Richard A. Schoettger ◽  
Wayne A. Willford
Keyword(s):  
Rainbow Trout ◽  
Aromatic Amines ◽  
Recovery Period ◽  
Free Drug ◽  
Salmo Gairdneri ◽  
Blood Levels ◽  
Drug Elimination ◽  
Drug Excretion ◽  
Anesthetic Concentration ◽  
Low Levels

Rainbow trout: (Salmo gairdneri) anesthetized in 100 mg/liter of M.S. 222 at 12 C excreted the drug in free and acetylated forms via the urine during a 24-hr recovery period in freshwater. Of the M.S. 222 excreted, 77–96% was acetylated. Blood levels of free drug in anesthetized trout approximated 75% of the anesthetic concentration, but the amount of acetylated M.S. 222 was relatively insignificant. The blood and urine were cleared of the two fractions of M.S. 222 in 8 and 24 hr respectively. Low levels of aromatic amines of natural origin occurred in blood and urine and were subtracted from measurements of M.S. 222. Intraperitoneal injections of 10–100 mg/kg of M.S. 222 did not induce anesthesia; however, the 24-hr pattern of drug excretion was similar to that observed after anesthesia by immersion. Only 15–21% of the injected dose was found in the urine, suggesting a second route of drug elimination.

Acute Toxicity of Nitrite to Rainbow Trout (Salmo gairdneri)

1974 ◽  
Vol 31 (10) ◽  
pp. 1653-1655 ◽  
Author(s):  
Rosemarie C. Russo ◽  
Charlie E. Smith ◽  
Robert V. Thurston
Keyword(s):  
Rainbow Trout ◽  
Acute Toxicity ◽  
Lethal Concentration ◽  
Salmo Gairdneri ◽  
Median Lethal Concentration ◽  
Flow Through

Flow-through bioassays on the acute toxicity of nitrite to rainbow trout (Salmo gairdneri) of four different sizes (2–235 g) showed median lethal concentration (LC50) values for 4 days ranging from 0.19 to 0.39 mg/liter NO2–N. For 12-g rainbow trout the asymptotic LC50 was 0.14–0.15 mg/liter NO2–N after 8 days.

Sign in / Sign up

Export Citation Format

Share Document