Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study

2002 ◽  
Vol 46 (10) ◽  
pp. 1206-1211 ◽  
Author(s):  
M. Veien ◽  
J. V. Sørensen ◽  
F. Madsen ◽  
P. Juelsgaard
Keyword(s):  
Blood Loss ◽  
Total Knee Replacement ◽  
Tranexamic Acid ◽  
Knee Replacement ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Total Knee

Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Knee Replacement

2013 ◽  
Vol 95 (21) ◽  
pp. 1961-1968 ◽  
Author(s):  
Sattar Alshryda ◽  
James Mason ◽  
Manesh Vaghela ◽  
Praveen Sarda ◽  
Antoni Nargol ◽  
...  
Keyword(s):  
Blood Loss ◽  
Total Knee Replacement ◽  
Tranexamic Acid ◽  
Knee Replacement ◽  
Total Knee

A Randomized Controlled Study on the Use of Tourniquet in Primary Total Knee Arthroplasty

2022 ◽  
Author(s):  
Chaofan Zhang ◽  
Chun Hoi Yan ◽  
Ping Keung Chan ◽  
Henry Fu ◽  
Kwong Yuen Chiu
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Skin Incision ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Total Knee ◽  
Primary Total Knee

Abstract Background The use and the optimal timing of tourniquet during primary total knee arthroplasty (TKA) is controversial. Most previous studies failed to show clinically significant differences in different strategies. The aim of this study was to determine how three strategies of tourniquet application affect the outcome in TKA patients. Methods This was a prospective randomized controlled study. Patients who undergo TKA were randomized into one of the three groups (1:1:1 ratio): tourniquet inflated from skin incision to cement hardening, tourniquet from cement application to hardening, and tourniquet from skin incision to skin closure. The perioperative blood loss, limb swelling, and complications were recorded. The level of hemoglobin, hematocrit, C-reactive protein (CRP), interleukin (IL)-6, creatine kinase (CK), and lactate dehydrogenase (LDH) were determined. Patients' thigh and TKA wound pain, Knee Society knee score (KSKS) and Knee Society functional assessment (KSFA) scores, and rehabilitation parameters were evaluated. Results A total of 90 patients were enrolled. The baseline characteristics were comparable. We only found significant difference in the intraoperative blood loss (skin to cement: 58.7 ± 36.1 mL, cement-only: 147.8 ± 107.9 mL, skin to skin: 16.3 ± 13.1 mL, p < 0.0001). There were no statistical differences in postoperative drainage, thigh/knee circumference, change of hemoglobin/hematocrit, CRP, IL-6, CK, and LDH on day 1 to day 4 after surgery. The thigh/TKA wound Visual Analogue Scale scores, KSKS score, KSFA score, and rehabilitation parameters were not significantly different at up to 6-month follow-up. No thromboembolic events were noted. Conclusion Our results revealed that there was no best tourniquet strategy in TKA. Different tourniquet methods can be utilized based on surgeon preference without affecting outcomes.

Intravenous vs Topical Tranexamic Acid in Total Knee Arthroplasty Without Tourniquet Application: A Randomized Controlled Study

2016 ◽  
Vol 31 (11) ◽  
pp. 2465-2470 ◽  
Author(s):  
Themistoklis K. Tzatzairis ◽  
Georgios I. Drosos ◽  
Stamatios E. Kotsios ◽  
Athanasios N. Ververidis ◽  
Theodosia D. Vogiatzaki ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Total Knee ◽  
Without Tourniquet ◽  
Topical Tranexamic Acid

scholarly journals Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement

2011 ◽  
Vol 6 (1) ◽  
pp. 22 ◽  
Author(s):  
Yasir J Sepah ◽  
Masood Umer ◽  
Tashfeen Ahmad ◽  
Faria Nasim ◽  
Muhammad Umer Chaudhry ◽  
...  
Keyword(s):  
Blood Loss ◽  
Total Knee Replacement ◽  
Tranexamic Acid ◽  
Knee Replacement ◽  
Cost Effective ◽  
Cost Effective Method ◽  
Total Knee

scholarly journals The role of tranexamic acid in reducing blood loss in total knee replacement

2013 ◽  
Vol 4 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Virender Kumar Gautam ◽  
Balaji Sambandam ◽  
Shailendra Singh ◽  
Prince Gupta ◽  
Rajat Gupta ◽  
...  
Keyword(s):  
Blood Loss ◽  
Total Knee Replacement ◽  
Tranexamic Acid ◽  
Knee Replacement ◽  
Total Knee
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