A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

2004 ◽  
Vol 118 (6) ◽  
pp. 1317-1323 ◽  
Author(s):  
Gwen Lagoda ◽  
John W. Muschamp ◽  
Anna Vigdorchik ◽  
Elaine M. Hull
Keyword(s):  
Nitric Oxide ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Male Rats ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibitor

Diurnal rhythm in cyclic GMP/nitric oxide efflux in the medial preoptic area of male rats

1998 ◽  
Vol 808 (2) ◽  
pp. 310-312 ◽  
Author(s):  
Shuye Pu ◽  
Pushpa S Kalra ◽  
Satya P Kalra
Keyword(s):  
Nitric Oxide ◽  
Cyclic Gmp ◽  
Diurnal Rhythm ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Male Rats

Sexual experience increases nitric oxide synthase in the medial preoptic area of male rats.

2006 ◽  
Vol 120 (6) ◽  
pp. 1389-1394 ◽  
Author(s):  
Juan M. Dominguez ◽  
Jessica H. Brann ◽  
Mario Gil ◽  
Elaine M. Hull
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Preoptic Area ◽  
Sexual Experience ◽  
Medial Preoptic Area ◽  
Male Rats ◽  
Oxide Synthase

Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

1998 ◽  
Vol 274 (1) ◽  
pp. R243-R247 ◽  
Author(s):  
Yoshikazu Sato ◽  
Hiroki Horita ◽  
Toshie Kurohata ◽  
Hideki Adachi ◽  
Taiji Tsukamoto
Keyword(s):  
Nitric Oxide ◽  
Preoptic Area ◽  
Copulatory Behavior ◽  
Medial Preoptic Area ◽  
In Vivo Microdialysis ◽  
Male Rats ◽  
Nitric Oxide Level ◽  
Synthase Inhibitor ◽  
Male Copulatory Behavior

We investigated the influence of the extracellular nitric oxide (NO) level on male copulatory behavior. We confirmed the changes of nitrite ([Formula: see text]) and nitrate ([Formula: see text]) in the medial preoptic area (MPOA) by administration of the NO precursorl-arginine (l-Arg, 10 mM) or the NO synthase inhibitor N G-monomethyl-l-arginine (l-NMMA, 10 mM) via a dialysis probe. [Formula: see text] and[Formula: see text] were measured simultaneously by an in vivo microdialysis method coupled with the Griess reaction.l-Arg induced significant elevations of extracellular [Formula: see text]and [Formula: see text].l-NMMA significantly reduced[Formula: see text] and[Formula: see text] levels. We observed male copulatory behavior during infusion ofl-Arg orl-NMMA. The mount rate of male rats significantly increased during infusion ofl-Arg in the MPOA. Administration of l-NMMA reduced the mount rate. These findings suggested that the elevation of extracellular NO in the MPOA facilitates male copulatory behavior of rats, whereas the decrease of NO reduces their copulatory behavior.

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