Case Studies Within Psychotherapy Trials: Integrating Qualitative and Quantitative Methods presents a specific, mixed-methods approach, called the “Cases Within Trials” (CWT) model, to psychotherapy research combining the results from a randomized clinical trial (RCT); the results of richly and qualitatively detailed systematic case studies involving contrasting outcomes drawn from the experimental condition of the RCT; and a synthesis of the two types of knowledge. Chapter 4 of the book applies this model to a study of the application of a group-based, interpersonal therapy treatment—called “Interpersonal Psychotherapy—Adolescent Skills Training” (IPT-AST)—in preventing depression in adolescents. Finding a substantial statistical advantage of the interpersonal treatment over a “school counseling as usual” condition, the authors then analyze and compare the positive-outcome case of Menorka with the negative-outcome case of Shelly, both drawn from the IPT-AST condition.