This chapter provides a brief overview of the research on trauma, specifically in relation to the impact of developmental and complex trauma and sexual abuse. An overview of the growing body of research on trauma-informed approaches to practice is also given. It considers how trauma responses are developed while enduring extreme stress, and how these responses may be evident among children and young people with child sexual exploitation (CSE) experiences. The chapter also considers how systems designed to protect and support traumatised children and young people often contribute to their re-traumatisation. It explores principles of trauma-informed practice that are useful in meeting the needs of young people victimised by CSE, discusses how trauma-informed approaches align with strengths-based and relationship-based approaches to CSE practice, and how such approaches can help practitioners understand and promote resilience.