scholarly journals D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress

2017 ◽  
Vol 39 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Shuang-shuang Zhao ◽  
Na-ren Li ◽  
Wu-li Zhao ◽  
Hong Liu ◽  
Mao-xu Ge ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bile Acid ◽  
Bile Duct ◽  
Acid Secretion ◽  
Bile Acid Secretion

scholarly journals Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability.

1983 ◽  
Vol 258 (6) ◽  
pp. 3661-3667 ◽  
Author(s):  
R A Davis ◽  
P M Hyde ◽  
J C Kuan ◽  
M Malone-McNeal ◽  
J Archambault-Schexnayder
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Rat Hepatocytes ◽  
Cultured Rat Hepatocytes ◽  
Bile Acid Secretion

Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats

2015 ◽  
Vol 71 (3) ◽  
pp. 1569-1577 ◽  
Author(s):  
Yue She ◽  
Hansong Zhao ◽  
Yanzhu Zhu ◽  
Yanfei Han ◽  
Shiliang Xia ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Hepatocyte Apoptosis ◽  
Aluminum Trichloride ◽  
Bile Acid Secretion

scholarly journals UNCOUPLING OF BILIARY LIP ID SECRETION FROM BILE ACID SECRETION BY ORGANIC ANIONS, DUE TO INTRACANALICULAR INTERACTION WITH BILE ACIDS

1989 ◽  
Vol 26 (3) ◽  
pp. 282-282
Author(s):  
H J Verkade ◽  
M J Wolbers ◽  
R Havinga ◽  
R J Vonk ◽  
F Kuipers
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Bile Acids ◽  
Organic Anions ◽  
Bile Acid Secretion

Differing effects of norcholate and cholate on bile flow and biliary lipid secretion in the rat

1984 ◽  
Vol 246 (1) ◽  
pp. G67-G71
Author(s):  
E. R. O'Maille ◽  
S. V. Kozmary ◽  
A. F. Hofmann ◽  
D. Gurantz
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Bile Acids ◽  
Bile Flow ◽  
Critical Micellar Concentration ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Unit Increase ◽  
Cholesterol Secretion ◽  
Bile Acid Secretion

The effects of norcholate (a C23 bile acid that differs from cholate in having a side chain containing four rather than five carbon atoms) on bile flow and biliary lipid secretion were compared with those of cholate, using the anesthetized rat with a bile fistula. Norcholate and cholate were infused intravenously over the range of 0.6-6.0 mumol X min-1 X kg-1. Both bile acids were quantitatively secreted into bile; norcholate was secreted predominantly in unconjugated form in contrast to cholate, which was secreted predominantly as its taurine or glycine conjugates. The increase in bile flow per unit increase in bile acid secretion induced by norcholate infusion [17 +/- 3.2 (SD) microliters/mumol, n = 8] was much greater than that induced by cholate infusion (8.6 +/- 0.9 microliters/mumol, n = 9) (P less than 0.001). Both bile acids induced phospholipid and cholesterol secretion. For an increase in bile acid secretion (above control values) of 1 mumol X min-1 X kg-1, the increases in phospholipid secretion [0.052 +/- 0.024 (SD) mumol X min-1 X kg-1, n = 9] and cholesterol secretion (0.0071 +/- 0.0033 mumol X min-1 X kg-1, n = 9) induced by norcholate infusion were much less than those induced by cholate infusion (0.197 +/- 0.05 mumol X min-1 X kg-1, n = 9, and 0.024 +/- 0.011 mumol X min-1 X kg-1, n = 9, respectively; P less than 0.001 for both phospholipid and cholesterol). The strikingly different effects of norcholate on bile flow and biliary lipid secretion were attributed mainly to its possessing a considerably higher critical micellar concentration than cholate.

Bile acid secretion following release of biliary obstruction

1979 ◽  
Vol 14 (6) ◽  
pp. 553-564 ◽  
Author(s):  
Uhyong Hyon ◽  
Masaru Yoshida
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Biliary Obstruction ◽  
Bile Acid Secretion

Effect of choleretics on canalicular transport of protoporphyrin in the rat liver

1982 ◽  
Vol 242 (4) ◽  
pp. G347-G353
Author(s):  
D. L. Avner ◽  
M. M. Berenson
Keyword(s):  
Bile Acid ◽  
Acid Secretion ◽  
Transport Process ◽  
Bile Flow ◽  
Ethacrynic Acid ◽  
Sodium Taurocholate ◽  
Secretory Process ◽  
Sodium Dehydrocholate ◽  
Major Route ◽  
Bile Acid Secretion

The major route of protoporphyrin elimination is biliary secretion. To clarify the nature of the secretory process, maximal canalicular secretion of protoporphyrin was determined under basal conditions and after treatment with various choleretics. The maximal secretion of protoporphyrin under basal conditions was 0.07 +/- 0.01 micrograms.min-1.100 g body wt-1. Infusion of physiological amounts of sodium taurocholate increased protoporphyrin secretion 13-fold (0.90 +/- 0.02), primarily by increasing the biliary protoporphyrin concentration. Biliary protoporphyrin secretion tended to plateau in spite of a continued rise in both biliary bile acid secretion and concentration. Infusion of sodium dehydrocholate increased protoporphyrin secretion, but to only 35% of that achieved by sodium taurocholate. Ethacrynic acid and phenobarbital increased bile flow over controls but failed to enhance protoporphyrin transport. Thus, canalicular secretion of protoporphyrin was maximally enhanced by micelle-forming bile acids and unaffected by nonbile acid choleretics. The observed limitation of protoporphyrin secretion may be related to achievement of a canalicular transport maximum or to a toxic effect of protoporphyrin on the transport process.

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