scholarly journals Long-term efficacy of infliximab on background vascular leakage in patients with Behçet’s disease

Eye ◽  
2014 ◽  
Vol 28 (9) ◽  
pp. 1100-1106 ◽  
Author(s):  
H Keino ◽  
A A Okada ◽  
T Watanabe ◽  
W Taki
2016 ◽  
Vol 56 (2) ◽  
pp. 218-220 ◽  
Author(s):  
Giacomo Emmi ◽  
Elena Silvestri ◽  
Danilo Squatrito ◽  
Antonio Vitale ◽  
Daniela Bacherini ◽  
...  

2017 ◽  
Vol 36 (9) ◽  
pp. 2063-2069 ◽  
Author(s):  
Antonio Vitale ◽  
Giacomo Emmi ◽  
Giuseppe Lopalco ◽  
Claudia Fabiani ◽  
Stefano Gentileschi ◽  
...  

2020 ◽  
pp. bjophthalmol-2020-316892
Author(s):  
Hiroshi Keino ◽  
Takayo Watanabe ◽  
Makiko Nakayama ◽  
Yoshinori Komagata ◽  
Kazuhito Fukuoka ◽  
...  

BackgroundTo evaluate long-term efficacy of infliximab (IFX) in refractory uveoretinitis associated with Behçet’s disease (BD) depending on uveoretinitis duration.MethodsRecords of 16 patients with BD (32 eyes) followed for >5 years after starting IFX, were retrospectively reviewed. Long-term efficacy was compared between patients with short duration (≤18 months, n=7) versus long duration (>18 months, n=9) of their uveoretinitis prior to starting IFX.ResultsThe median follow-up after starting IFX was 132 months (76–146 months). Mean frequency of attacks and the 1-year Behçet’s Disease Ocular Attack Score 24 decreased significantly over 10 years. Overall, the percentage of eyes with a best-corrected visual acuity (BCVA) ≥1.0 increased from 47% at baseline to 59% at 5 years; the percentage of eyes with a BCVA ≤0.1 was 19% at both baseline and 5 years. The frequency of ocular attacks decreased similarly in both short duration and long duration groups; however, the percentage of eyes with a BCVA ≥1.0 at 5 years was 100% in the short duration group versus 28% in the long duration group. IFX was discontinued in four patients with an excellent response to IFX therapy; all were young male patients in the short duration group with good BCVA bilaterally, and none had inflammatory recurrences over a median follow-up of 56 months off IFX.ConclusionInitiation of IFX therapy in patients with BD within 18 months of their uveoretinitis onset was more effective in maintaining good BCVA than after 18 months.


Rheumatology ◽  
2007 ◽  
Vol 46 (7) ◽  
pp. 1161-1164 ◽  
Author(s):  
L. Niccoli ◽  
C. Nannini ◽  
M. Benucci ◽  
D. Chindamo ◽  
E. Cassara ◽  
...  

2016 ◽  
Vol 35 (11) ◽  
pp. 2765-2769 ◽  
Author(s):  
Hadise Kavandi ◽  
Alireza Khabbazi ◽  
Sousan Kolahi ◽  
Mehrzad Hajialilo ◽  
Farid Karkon Shayan ◽  
...  

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A638.3-A638
Author(s):  
P. Leccese ◽  
L. Latanza ◽  
A. Padula ◽  
A. Nigro ◽  
S. D’Angelo ◽  
...  

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