scholarly journals Immunochemistry of urinary calcium oxalate crystal growth inhibitor (CGI)

1986 ◽  
Vol 29 (4) ◽  
pp. 829-833 ◽  
Author(s):  
Michelle Lopez ◽  
Yasushi Nakagawa ◽  
Frederic L. Coe ◽  
Cheng Tsai ◽  
Alfred F. Michael ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Growth Inhibitor ◽  
Urinary Calcium ◽  
Calcium Oxalate Crystal

scholarly journals Urinary calcium oxalate crystal growth inhibitors.

1994 ◽  
Vol 5 (5) ◽  
pp. S46
Author(s):  
E M Worcester
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Bone Matrix ◽  
Urinary Calcium ◽  
Crystal Nucleation ◽  
Calcium Oxalate Crystal ◽  
Stone Formers ◽  
High Concentrations ◽  
Renal Tubular

Calcium stones occur because renal tubular fluid and urine are supersaturated with respect to calcium oxalate and phosphate. The process of stone formation includes crystal nucleation, growth, aggregation, and attachment to renal epithelia. Urine contains macromolecules that modify these processes and may protect against stone formation. Attention has focused especially on inhibitors of crystal growth, and several have been isolated from urine, including nephrocalcin, an acidic phosphorylated glycoprotein that contains several residues of gamma-carboxyglutamic acid per molecule; osteopontin (uropontin), a phosphorylated glycoprotein also found in bone matrix; uronic acid-rich protein, which contains a covalently bound glycosaminoglycan residue; and several others. Abnormalities in structure and/or function have been detected in some of these proteins in stone formers' urine. However, the overall ability of urinary macromolecules to inhibit calcium oxalate crystal growth is often normal in stone formers. Recently, attention has been focused on the ability of these molecules to inhibit other stages in stone formation. Nephrocalcin can inhibit crystal nucleation, for example, and both nephrocalcin and Tamm-Horsfall protein inhibit crystal aggregation. Nephrocalcin and Tamm-Horsfall protein from stone formers are less active in preventing aggregation, and under some conditions, Tamm-Horsfall protein may promote the formation of crystal aggregates, especially in the presence of high concentrations of calcium. The structural abnormalities responsible for impaired inhibitory activity are not completely understood.

The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin

2009 ◽  
Vol 7 (9) ◽  
pp. 1029-1036 ◽  
Author(s):  
Elaine M. Worcester ◽  
Samuel S. Blumenthal ◽  
Ann M. Beshensky ◽  
Donna L. Lewand
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Growth Inhibitor ◽  
Mouse Kidney ◽  
Inhibitor Protein ◽  
Calcium Oxalate Crystal ◽  
Cortical Cells ◽  
Cells In Culture

Inhibition of Calcium Oxalate Crystal Growth in Patients with Urolithiasis

Urolithiasis ◽  
1981 ◽  
pp. 623-629 ◽  
Author(s):  
Hans-Göran Tiselius ◽  
Lasse Larsson
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal

Bacteria can promote calcium oxalate crystal growth and aggregation

2013 ◽  
Vol 18 (3) ◽  
pp. 299-308 ◽  
Author(s):  
Somchai Chutipongtanate ◽  
Suchitra Sutthimethakorn ◽  
Wararat Chiangjong ◽  
Visith Thongboonkerd
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin
Sign in / Sign up

Export Citation Format

Share Document