Calcium Oxalate Crystal Growth: Investigations on Inhibitory Activity of Model Compounds and Urine Samples

1985 ◽  
pp. 851-854 ◽  
Author(s):  
J. Joost ◽  
M. Lusser ◽  
K. Kleboth
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Inhibitory Activity ◽  
Urine Samples ◽  
Calcium Oxalate Crystal ◽  
Model Compounds

scholarly journals ISOLATION OF URINARY HEPARAN SULFATE AND CHONDROITIN SULFATE AND THEIR INHIBITORY ACTIVITY OF CALCIUM OXALATE CRYSTAL GROWTH

1991 ◽  
Vol 82 (3) ◽  
pp. 405-411 ◽  
Author(s):  
Hidenobu Iwata ◽  
Takashi Terado ◽  
Masahiro Kin ◽  
Shunji Nishio ◽  
Masafumi Takeuchi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Heparan Sulfate ◽  
Chondroitin Sulfate ◽  
Inhibitory Activity ◽  
Calcium Oxalate Crystal

Evaluation of a routine method for determination of calcium oxalate crystal growth inhibition in diluted urine samples.

1981 ◽  
Vol 27 (4) ◽  
pp. 565-568 ◽  
Author(s):  
H G Tiselius ◽  
A M Fornander
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Urine Samples ◽  
Sodium Oxalate ◽  
Control Group ◽  
Routine Method ◽  
Calcium Oxalate Crystal ◽  
Good Correspondence ◽  
Inhibition Index

Abstract We have evaluated a routine method for determination of the inhibition of calcium oxalate crystal growth in diluted urine samples. A crystallization inhibition index is calculated from the decrease in [14C]oxalate concentration in a metastable solution of calcium chloride and sodium oxalate after addition of seed crystals of calcium oxalate. The coefficient of variation between different determinations on the same sample is less than 1.5%, and there is good correspondence between indices obtained by this method and by a more laborious older method. We also studied the influence of different urinary constituents on the crystal growth rate in the system; whereas there was significant inhibition with citrate, chondritin sulfate, and pyrophosphate, no effects were observed with ordinary urinary concentrations of calcium, magnesium, and oxalate. The mean inhibition index was lower in a group of male patients with calcium oxalate stone disease than in a control group of normal men.

scholarly journals FKBP-12 Exhibits an Inhibitory Activity on Calcium Oxalate Crystal Growth in Vitro

2002 ◽  
Vol 17 (1) ◽  
pp. 41 ◽  
Author(s):  
In Sook Han ◽  
Yasushi Nakagawa ◽  
Jong Wook Park ◽  
Min Ho Suh ◽  
Sung IL Suh ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Inhibitory Activity ◽  
Calcium Oxalate Crystal

Inhibitory Activity of Human Urine on Calcium Oxalate Crystal Growth: Effects of Sodium Urate and Uric Acid

1982 ◽  
Vol 62 (5) ◽  
pp. 509-514 ◽  
Author(s):  
B. Fellström ◽  
U. Backman ◽  
B. G. Danielson ◽  
K. Holmgren ◽  
S. Ljunghall ◽  
...  
Keyword(s):  
Uric Acid ◽  
Crystal Growth ◽  
Calcium Oxalate ◽  
Inhibitory Activity ◽  
Calcium Oxalate Crystal ◽  
Molecular Fraction ◽  
Almost All ◽  
Pronounced Reduction ◽  
Sodium Urate ◽  
Urate Crystals

1. Freshly voided urine from healthy subjects was pooled and ultrafiltered (10 000 daltons). The ultrafiltrable and the macromolecular portions were preincubated with calcium oxalate, uric acid and sodium urate crystals and the effects on the inhibitory activity of calcium oxalate crystal growth assessed by monitoring the disappearance of [14C]oxalate from the solution. 2. The inhibitory activity of the ultrafiltrate was higher than that of the urinary macro-molecular fraction. Both uninhibited and inhibited crystal growth processes followed second-order kinetics. 3. Calcium oxalate crystals adsorbed almost all the urinary macromolecular inhibitors whereas sodium urate or uric acid crystals adsorbed only 10–20%. 4. In the presence of a metastable solution of calcium oxalate, the incubation of the urinary macromolecular fraction with sodium urate crystals caused a pronounced reduction in the inhibitory activity. A similar effect was seen with uric acid crystals, but to a lesser degree. 5. We conclude that the effect of sodium urate or uric acid crystals alone on naturally occurring urinary macromolecular inhibitors of calcium oxalate crystal growth is weak, but that in the presence of metastable calcium oxalate this is greatly enhanced. A substantial adsorption of the inhibitors on to the crystals is suggested, possibly secondary to epitaxial growth of calcium oxalate on the surface of the urate crystals.

Inhibition of Calcium Oxalate Crystal Growth in Patients with Urolithiasis

Urolithiasis ◽  
1981 ◽  
pp. 623-629 ◽  
Author(s):  
Hans-Göran Tiselius ◽  
Lasse Larsson
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal

Bacteria can promote calcium oxalate crystal growth and aggregation

2013 ◽  
Vol 18 (3) ◽  
pp. 299-308 ◽  
Author(s):  
Somchai Chutipongtanate ◽  
Suchitra Sutthimethakorn ◽  
Wararat Chiangjong ◽  
Visith Thongboonkerd
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Calcium Oxalate Crystal

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin

scholarly journals Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.

1992 ◽  
Vol 89 (1) ◽  
pp. 426-430 ◽  
Author(s):  
H. Shiraga ◽  
W. Min ◽  
W. J. VanDusen ◽  
M. D. Clayman ◽  
D. Miner ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Aspartic Acid ◽  
Calcium Oxalate Crystal ◽  
Protein Superfamily
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