scholarly journals Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns

2010 ◽  
Vol 23 (9) ◽  
pp. 1191-1200 ◽  
Author(s):  
Michael Rivera ◽  
Julio Ricarte-Filho ◽  
Jeff Knauf ◽  
Ashok Shaha ◽  
Michael Tuttle ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Histological Subtypes ◽  
Follicular Variant ◽  
Ras Mutation ◽  
Molecular Genotyping

scholarly journals Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tae Sook Hwang ◽  
Wook Youn Kim ◽  
Hye Seung Han ◽  
So Dug Lim ◽  
Wan-Seop Kim ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Mutational Analysis ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Ras Mutation ◽  
Ras Mutations ◽  
Codon 61

Follicular variant of papillary thyroid carcinoma (FVPTC), particularly the encapsulated subtype, often causes a diagnostic dilemma. We reconfirmed the molecular profiles in a large number of FVPTCs and investigated the efficacy of the preoperative mutational analysis in indeterminate thyroid nodules. BRAF V600E/K601E and RAS mutational analysis was performed on 187 FVPTCs. Of these, 132 (70.6%) had a point mutation in one of the BRAF V600E (n=57), BRAF K601E (n=11), or RAS (n=64) genes. All mutations were mutually exclusive. The most common RAS mutations were at NRAS codon 61. FNA aspirates from 564 indeterminate nodules were prospectively tested for BRAF and RAS mutation and the surgical outcome was correlated with the mutational status. Fifty-seven and 47 cases were positive for BRAF and RAS mutation, respectively. Twenty-seven RAS-positive patients underwent surgery and all except one patient had FVPTC. The PPV and accuracy of RAS mutational analysis for predicting FVPTC were 96% and 84%, respectively. BRAF or RAS mutations were present in more than two-thirds of FVPTCs and these were mutually exclusive. BRAF mutational analysis followed by N, H, and KRAS codon 61 mutational analysis in indeterminate thyroid nodules would streamline the management of patients with malignancies, mostly FVPTC.

Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma

2017 ◽  
Vol 72 (4) ◽  
pp. 648-661 ◽  
Author(s):  
Tae Hyuk Kim ◽  
Minju Lee ◽  
Ah-Young Kwon ◽  
Jun-Ho Choe ◽  
Jung-Han Kim ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Molecular Genotyping ◽  
Non Invasive

RAS Mutation-Positive Follicular Variant of Papillary Thyroid Carcinoma Arising in a Struma Ovarii

2009 ◽  
Vol 21 (2) ◽  
pp. 144-147 ◽  
Author(s):  
Christopher Coyne ◽  
Yuri E. Nikiforov
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Struma Ovarii ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Ras Mutation

scholarly journals Molecular Genotyping of Follicular Variant of Papillary Thyroid Carcinoma Correlates with Diagnostic Category of Fine-Needle Aspiration Cytology: Values of RAS Mutation Testing

Thyroid ◽  
2013 ◽  
Vol 23 (11) ◽  
pp. 1416-1422 ◽  
Author(s):  
Sang Ryung Lee ◽  
Chan Kwon Jung ◽  
Tae Eun Kim ◽  
Ja Seong Bae ◽  
So Lyung Jung ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Diagnostic Category ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Aspiration Cytology ◽  
Ras Mutation ◽  
Fine Needle ◽  
Molecular Genotyping ◽  
Needle Aspiration Cytology

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

2017 ◽  
Author(s):  
Fernando Garcia Perez ◽  
Guillermo Martinez de Pinillos Gordillo ◽  
Mariana Tome Fernandez-Ladreda ◽  
Eyvee Arturo Cuellar Lloclla ◽  
Jose Alvaro Romero Porcel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Initial Size ◽  
Histological Features

A Greek Family with a Follicular Variant of Familial Papillary Thyroid Carcinoma: TCO, MNG1, fPTC/PRN, and NMTC1 Excluded as Susceptibility Loci

Thyroid ◽  
2005 ◽  
Vol 15 (12) ◽  
pp. 1349-1354 ◽  
Author(s):  
Tasoula Tsilchorozidou ◽  
Eleni Vafiadou ◽  
John G. Yovos ◽  
Giovani Romeo ◽  
James McKay ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Susceptibility Loci ◽  
Follicular Variant

scholarly journals Cutaneous metastases on the head and neck from a papillary thyroid carcinoma, follicular variant

2016 ◽  
Vol 107 (1) ◽  
pp. 83-85
Author(s):  
A. Márquez García ◽  
L. Ferrándiz Pulido ◽  
J.J. Ríos-Martín ◽  
F.M. Camacho Martínez
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Head And Neck ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Cutaneous Metastases
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