scholarly journals Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model

2016 ◽  
Vol 24 (2) ◽  
pp. 342-353 ◽  
Author(s):  
Miguel G Toscano ◽  
Pilar Muñoz ◽  
Almudena Sánchez-Gilabert ◽  
Marién Cobo ◽  
Karim Benabdellah ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Megakaryocytic Differentiation ◽  
Stem Cell Model

Human embryonic stem cell model of ethanol-mediated early developmental toxicity

2012 ◽  
Vol 234 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Rodney Nash ◽  
Malini Krishnamoorthy ◽  
Andrew Jenkins ◽  
Marie Csete
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Developmental Toxicity ◽  
Embryonic Stem ◽  
Stem Cell Model ◽  
Early Developmental

scholarly journals The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model

2020 ◽  
Author(s):  
Ioannis Bantounas ◽  
Filipa M. Lopes ◽  
Kirsty M. Rooney ◽  
Adrian S. Woolf ◽  
Susan J. Kimber
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Stem Cell Model

scholarly journals Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome

2019 ◽  
Vol 39 ◽  
pp. 101508
Author(s):  
Aleksey Y. Domozhirov ◽  
John L. Mazzilli ◽  
Rick A. Wetsel ◽  
Eva M. Zsigmond
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Stem Cell Model

scholarly journals A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

2019 ◽  
Vol 13 ◽  
Author(s):  
Teresa Ubina ◽  
Martha Magallanes ◽  
Saumya Srivastava ◽  
Charles D. Warden ◽  
Jiing-Kuan Yee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Stem Cell Model ◽  
Progressive Neurodegeneration

scholarly journals A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegeneration

2018 ◽  
Author(s):  
Teresa Ubina ◽  
Martha Magallanes ◽  
Saumya Srivastava ◽  
Charles Warden ◽  
Jiing-Kuan Yee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Phenotypic Analysis ◽  
Pathway Annotation ◽  
Abnormal Accumulation ◽  
Stem Cell Model ◽  
Progressive Neurodegeneration

AbstractWe describe construction and phenotypic analysis of a human embryonic stem cell model of progressive Aβ-dependent neurodegeneration (ND) with potential relevance to Alzheimer’s disease (AD). We modified one allele of the normal APP locus to directly express a secretory form of Aβ40 or Aβ42, eliminating the need for amyloidogenic APP proteolysis. Following neuronal differentiation edited cell lines specifically accumulate aggregated/oligomeric Aβ, exhibit a synaptic deficit and have an abnormal accumulation of endolysosomal vesicles. Edited cultures progress to a stage of overt ND. All phenotypes appear at earlier culture times for Aβ42 relative to Aβ40. Whole transcriptome RNA-Seq analysis identified 23 up and 70 down regulated genes (DEGs) with similar directional fold change but larger absolute values in the Aβ42 samples suggesting common underlying pathogenic mechanisms. Pathway/annotation analysis suggested that down regulation of extracellular matrix and cilia functions are significantly overrepresented. This cellular model could be useful for uncovering mechanisms directly linking Aβ to neuronal death and as a tool to screen for new therapeutic agents that slow or prevent human ND.

scholarly journals Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders.

Hypertension ◽  
1993 ◽  
Vol 22 (4) ◽  
pp. 618-629 ◽  
Author(s):  
T Doetschman ◽  
M Shull ◽  
A Kier ◽  
J D Coffin
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Model Systems ◽  
Vascular Morphogenesis ◽  
Stem Cell Model ◽  
Cardiac Disorders

scholarly journals A Bmp Reporter Transgene Mouse Embryonic Stem Cell Model as a Tool to Identify and Characterize Chemical Teratogens

2015 ◽  
Vol 146 (2) ◽  
pp. 374-385 ◽  
Author(s):  
Josephine Kugler ◽  
Julian Tharmann ◽  
Susana M. Chuva de Sousa Lopes ◽  
Rolf Kemler ◽  
Andreas Luch ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Stem Cell Model ◽  
Reporter Transgene
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