Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Johanna Flach; Sietske T. Bakker; Mary Mohrin; Pauline C. Conroy; Eric M. Pietras; Damien Reynaud; Silvia Alvarez; Morgan E. Diolaiti; Fernando Ugarte; E. Camilla Forsberg; Michelle M. Le Beau; Bradley A. Stohr; Juan Méndez; Ciaran G. Morrison; Emmanuelle Passegué

doi:10.1038/nature13619

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Nature ◽

10.1038/nature13619 ◽

2014 ◽

Vol 512 (7513) ◽

pp. 198-202 ◽

Cited By ~ 325

Author(s):

Johanna Flach ◽

Sietske T. Bakker ◽

Mary Mohrin ◽

Pauline C. Conroy ◽

Eric M. Pietras ◽

...

Keyword(s):

Stem Cells ◽

Functional Decline ◽

Replication Stress ◽

Haematopoietic Stem Cells

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Faculty Opinions recommendation of Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718513256.793499379 ◽

2014 ◽

Author(s):

Maarten van Lohuizen ◽

Gaetano Gargiulo

Keyword(s):

Stem Cells ◽

Functional Decline ◽

Replication Stress ◽

Haematopoietic Stem Cells

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Faculty Opinions recommendation of Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718513256.793499378 ◽

2014 ◽

Author(s):

Ian D Hickson ◽

Hocine W Mankouri

Keyword(s):

Stem Cells ◽

Functional Decline ◽

Replication Stress ◽

Haematopoietic Stem Cells

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Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen

British Journal of Haematology ◽

10.1046/j.1365-2141.2000.02454.x ◽

2000 ◽

Vol 111 (3) ◽

pp. 797-800 ◽

Cited By ~ 8

Author(s):

C. Craddock ◽

P. Bardy ◽

S. Kreiter ◽

R. Johnston ◽

J. Apperley ◽

...

Keyword(s):

Stem Cells ◽

T Cell ◽

Conditioning Regimen ◽

Reduced Intensity Conditioning ◽

Haematopoietic Stem Cells ◽

Reduced Intensity Conditioning Regimen ◽

Reduced Intensity

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Orphan designation: Autologous CD34+ haematopoietic stem cells transduced with lentiviral vector encoding the human betaA-T87Q-globin gene, Treatment of beta thalassaemia intermedia and major

Case Medical Research ◽

10.31525/cmr-de550e ◽

2019 ◽

Author(s):

Keyword(s):

Stem Cells ◽

Lentiviral Vector ◽

Globin Gene ◽

Haematopoietic Stem Cells ◽

Orphan Designation ◽

Beta Thalassaemia ◽

Gene Treatment ◽

Thalassaemia Intermedia

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Orphan designation: Autologous haematopoietic stem cells transduced with lentiviral vector Lenti-D encoding the human ABCD1 cDNA, Treatment of adrenoleukodystrophy

Case Medical Research ◽

10.31525/cmr-cc49d1 ◽

2019 ◽

Author(s):

Keyword(s):

Stem Cells ◽

Lentiviral Vector ◽

Haematopoietic Stem Cells ◽

Orphan Designation

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Faculty Opinions recommendation of Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087486.540536 ◽

2007 ◽

Author(s):

Lucio Comai

Keyword(s):

Stem Cells ◽

Dna Damage ◽

Dna Damage Repair ◽

Haematopoietic Stem Cells ◽

Damage Repair

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Faculty Opinions recommendation of DNA repair is limiting for haematopoietic stem cells during ageing.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087465.550780 ◽

2007 ◽

Author(s):

Dale Ramsden

Keyword(s):

Stem Cells ◽

Dna Repair ◽

Haematopoietic Stem Cells

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Faculty Opinions recommendation of Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090615.547815 ◽

2007 ◽

Author(s):

Hiten Madhani

Keyword(s):

Stem Cells ◽

Haematopoietic Stem Cells

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Faculty Opinions recommendation of Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090615.543909 ◽

2007 ◽

Author(s):

Peter Lansdorp

Keyword(s):

Stem Cells ◽

Haematopoietic Stem Cells

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Faculty Opinions recommendation of IFNalpha activates dormant haematopoietic stem cells in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1148918.618406 ◽

2009 ◽

Author(s):

Michael Deininger ◽

Paul La Rosée

Keyword(s):

Stem Cells ◽

Haematopoietic Stem Cells

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