Faculty Opinions recommendation of Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

2007 ◽  
Author(s):  
Lucio Comai
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Haematopoietic Stem Cells ◽  
Damage Repair

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Nature ◽  
2007 ◽  
Vol 447 (7145) ◽  
pp. 725-729 ◽  
Author(s):  
Derrick J. Rossi ◽  
David Bryder ◽  
Jun Seita ◽  
Andre Nussenzweig ◽  
Jan Hoeijmakers ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Haematopoietic Stem Cells ◽  
Damage Repair

scholarly journals Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination

2017 ◽  
Vol 9 (5) ◽  
pp. 1660-1674 ◽  
Author(s):  
Kalpana Mujoo ◽  
Raj K. Pandita ◽  
Anjana Tiwari ◽  
Vijay Charaka ◽  
Sharmistha Chakraborty ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Dna Damage Repair ◽  
Embryonic Stem ◽  
Damage Repair ◽  
Induced Pluripotent

scholarly journals C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells

Leukemia ◽  
2011 ◽  
Vol 26 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Y Satoh ◽  
I Matsumura ◽  
H Tanaka ◽  
H Harada ◽  
Y Harada ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Hematopoietic Stem Cells ◽  
Dna Damage Repair ◽  
Hematopoietic Stem ◽  
Damage Repair

scholarly journals Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML

2021 ◽  
Author(s):  
Grace Egan ◽  
G.E. Thomas ◽  
Parasvi Patel ◽  
Veronique Voisin ◽  
Rose Hurren ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Leukemia Stem Cells ◽  
Damage Repair

scholarly journals Mutant MEG3 Enhances the Activity of Telomerase by Increasing DNA Damage Repair in Human Liver Cancer Stem Cells

2021 ◽  
Author(s):  
Shuting Song ◽  
Sijie Xie ◽  
Rushi Qin ◽  
Yanan Lu ◽  
Liyan Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Dna Damage Repair ◽  
Liver Cancer Stem Cells ◽  
Damage Repair ◽  
Human Liver Cancer

Abstract Background: Long noncoding RNAs have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Although wild MEG3 acts as a suppressor in several cancers, the function of mutant MEG3 is also unclear during tumorigenesis.Methods: Lentivalus infection,RT-PCR,Western blotting and tumorigenesis test in vitro and in vivo were performed.Results: our results suggest that mutant MEG3 promotes the growth of human liver cancer stem cells in vivo and in vitro.Mechanistically, our results show that mutant MEG3 enhances acetylation modification of HistoneH4 on K16.Then, mutant MEG3 enhances the expression of SETD2 dependent on H4K16Ac.Moreover, mutant MEG3 increases the DNA damage repair through SETD2.Ultimately, mutant MEG3 increases the telomeras activity dependent on DNA damage repair.Strikingly,TERT determines the cancerous function of mutant MEG3 in liver cancer stem cells. Therefore, we shed light on the fact that targeting mutant MEG3 could be a viable approach for cancer treatment.Conclusions: these observations will play an important role in finding effective tumor treatment targets.

In Vitro Senescence of Rat Mesenchymal Stem Cells is Accompanied by Downregulation of Stemness-Related and DNA Damage Repair Genes

2009 ◽  
Vol 18 (7) ◽  
pp. 1033-1042 ◽  
Author(s):  
Umberto Galderisi ◽  
Heike Helmbold ◽  
Tiziana Squillaro ◽  
Nicola Alessio ◽  
Natascha Komm ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Mesenchymal Stem Cells ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Genes

scholarly journals MicroRNA 34a promotes ionizing radiation–induced DNA damage repair in murine hematopoietic stem cells

2019 ◽  
Vol 33 (7) ◽  
pp. 8138-8147 ◽  
Author(s):  
Hao Zeng ◽  
Mengjia Hu ◽  
Yukai Lu ◽  
Zihao Zhang ◽  
Yang Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Ionizing Radiation ◽  
Hematopoietic Stem Cells ◽  
Dna Damage Repair ◽  
Hematopoietic Stem ◽  
Damage Repair ◽  
Radiation Induced
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