Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia

Kenneth A Perkins; K N Roy Chengappa; Joshua L Karelitz; Margaret C Boldry; Valerie Michael; Taylor Herb; Jessica Gannon; Jaspreet Brar; Lisa Ford; Stefanie Rassnick; Darlene H Brunzell

doi:10.1038/npp.2017.292

Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia

Neuropsychopharmacology ◽

10.1038/npp.2017.292 ◽

2017 ◽

Vol 43 (6) ◽

pp. 1334-1342 ◽

Cited By ~ 6

Author(s):

Kenneth A Perkins ◽

K N Roy Chengappa ◽

Joshua L Karelitz ◽

Margaret C Boldry ◽

Valerie Michael ◽

...

Keyword(s):

Nicotinic Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Alpha 7

Download Full-text

S59. Alpha-7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator Galantamine in Autism Spectrum Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2018.02.950 ◽

2018 ◽

Vol 83 (9) ◽

pp. S369-S370

Author(s):

Asif Rahman ◽

Robert Freedman ◽

Eric Hollander

Keyword(s):

Autism Spectrum Disorder ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

Discovery of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration

Biochemical Pharmacology ◽

10.1016/j.bcp.2013.08.046 ◽

2013 ◽

Vol 86 (8) ◽

pp. 1231

Author(s):

Jesper F. Bastlund ◽

Christoffer Bundgaard ◽

Kim Dekermendjian ◽

Roger L. Papke ◽

John P. Redrobe ◽

...

Keyword(s):

Oral Administration ◽

Cognitive Deficits ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.11.022 ◽

2014 ◽

Vol 24 (1) ◽

pp. 288-293 ◽

Cited By ~ 19

Author(s):

Jørgen Eskildsen ◽

John P. Redrobe ◽

Anette G. Sams ◽

Kim Dekermendjian ◽

Morten Laursen ◽

...

Keyword(s):

Oral Administration ◽

Cognitive Deficits ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00364 ◽

2019 ◽

Vol 10 (8) ◽

pp. 3900-3909 ◽

Cited By ~ 2

Author(s):

María Jesús Pérez de Vega ◽

Cristina Fernandez-Mendivil ◽

Roberto de la Torre Martínez ◽

Sara González-Rodríguez ◽

José Mullet ◽

...

Keyword(s):

Nicotinic Receptors ◽

Neuroprotective Activity ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

Download Full-text

Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

Neuropharmacology ◽

10.1016/j.neuropharm.2012.10.019 ◽

2013 ◽

Vol 67 ◽

pp. 201-212 ◽

Cited By ~ 65

Author(s):

Patrick M. Callahan ◽

Elizabeth J. Hutchings ◽

Nancy J. Kille ◽

James M. Chapman ◽

Alvin V. Terry

Keyword(s):

Learning And Memory ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

Effects of alpha-7 nicotinic acetylcholine receptor positive allosteric modulator on lipopolysaccharide-induced neuroinflammatory pain in mice

European Journal of Pharmacology ◽

10.1016/j.ejphar.2016.05.003 ◽

2016 ◽

Vol 783 ◽

pp. 85-91 ◽

Cited By ~ 11

Author(s):

Muzaffar Abbas ◽

Shafiqur Rahman

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

(401) Brain alpha-7 nicotinic acetylcholine receptor positive allosteric modulator attenuates mechanical allodynia and hyperalgesia in a mouse model of neuroinflammatory pain

Journal of Pain ◽

10.1016/j.jpain.2016.01.378 ◽

2016 ◽

Vol 17 (4) ◽

pp. S75 ◽

Cited By ~ 1

Author(s):

M. Abbas ◽

S. Rahman

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Mechanical Allodynia ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Nicotinic Acetylcholine ◽

Alpha 7

Download Full-text

Electrophysiological characterization of NS9283, a novel positive allosteric modulator of α4β2 nicotinic receptors

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.07.021 ◽

2011 ◽

Vol 82 (8) ◽

pp. 1030

Author(s):

M. Grupe ◽

M. Grunnet ◽

J.K. Christensen ◽

A.A. Jensen ◽

P.K. Ahring

Keyword(s):

Nicotinic Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Electrophysiological Characterization

Download Full-text

Correction: Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2

Biochemical Journal ◽

10.1042/bcj-2019-0569_cor ◽

2020 ◽

Vol 477 (2) ◽

pp. 459-459

Author(s):

Lalith K. Chaganti ◽

Shubhankar Dutta ◽

Raja Reddy Kuppili ◽

Mriganka Mandal ◽

Kakoli Bose

Keyword(s):

Serine Protease ◽

Structural Modeling ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

Download Full-text

The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion

10.32469/10355/40222 ◽

2013 ◽

Author(s):

Diana Klakotskaia

Keyword(s):

Taste Aversion ◽

Conditioned Taste Aversion ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

Download Full-text