scholarly journals Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

Oncogene ◽  
2010 ◽  
Vol 29 (20) ◽  
pp. 2973-2982 ◽  
Author(s):  
F Zanella ◽  
O Renner ◽  
B García ◽  
S Callejas ◽  
A Dopazo ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Malignant Phenotype

scholarly journals Suppression of the Malignant Phenotype of Melanoma Cells by Anti-Oncogene Ribozymes

1996 ◽  
Vol 106 (2) ◽  
pp. 275-280 ◽  
Author(s):  
Yukinori Ohta ◽  
Hiroshi Kijima ◽  
Mohammed Kashani-Sabet ◽  
Kevin J. Scanlon
Keyword(s):  
Melanoma Cells ◽  
Malignant Phenotype

scholarly journals Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-κB

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 80765-80782 ◽  
Author(s):  
Biao Xie ◽  
Ke Cao ◽  
Jinjin Li ◽  
Jia Chen ◽  
Jintian Tang ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Malignant Phenotype

Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype

2018 ◽  
Vol 399 (9) ◽  
pp. 1099-1105 ◽  
Author(s):  
Meriem Haddada ◽  
Hend Draoui ◽  
Lydia Deschamps ◽  
Francine Walker ◽  
Tiphaine Delaunay ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Potential Role ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Integrin Expression ◽  
Spheroid Formation ◽  
Malignant Phenotype ◽  
Potential Therapeutic Target ◽  
Β3 Integrin

AbstractWe recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of α5/β1/αv/β3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.

scholarly journals The metastatic microenvironment: Melanoma-microglia cross-talk promotes the malignant phenotype of melanoma cells

2018 ◽  
Vol 144 (4) ◽  
pp. 802-817 ◽  
Author(s):  
Sivan Izraely ◽  
Shlomit Ben-Menachem ◽  
Orit Sagi-Assif ◽  
Alona Telerman ◽  
Inna Zubrilov ◽  
...  
Keyword(s):  
Cross Talk ◽  
Melanoma Cells ◽  
Malignant Phenotype ◽  
Metastatic Microenvironment

scholarly journals The metastatic microenvironment: Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain-metastasizing melanoma cells

2012 ◽  
Vol 131 (11) ◽  
pp. 2509-2518 ◽  
Author(s):  
Anat Klein ◽  
Orit Sagi-Assif ◽  
Sivan Izraely ◽  
Tsipi Meshel ◽  
Metsada Pasmanik-Chor ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Malignant Phenotype ◽  
Soluble Factors ◽  
Metastatic Microenvironment

scholarly journals OncogenicNRAShas multiple effects on the malignant phenotype of human melanoma cells culturedin vitro

2009 ◽  
Vol 124 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Malihe Eskandarpour ◽  
Fei Huang ◽  
Karen A. Reeves ◽  
Edwin Clark ◽  
Johan Hansson
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Malignant Phenotype ◽  
Human Melanoma Cells
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