scholarly journals Retinal Microvasculature and Visual Acuity after Intravitreal Aflibercept in Diabetic Macular Edema: An Optical Coherence Tomography Angiography Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Caleb Busch ◽  
Taku Wakabayashi ◽  
Tatsuhiko Sato ◽  
Yoko Fukushima ◽  
Chikako Hara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Retinal Microvasculature ◽  
Intravitreal Aflibercept

scholarly journals Optical coherence tomography angiography findings in diabetic macular edema

2021 ◽  
Vol 4 ◽  
pp. 3
Author(s):  
Rene Alfredo Cano-Hidalgo ◽  
Tatiana Urrea-Victoria
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Noninvasive Evaluation ◽  
Optical Coherence ◽  
Microvascular Changes ◽  
Levels Of Detail ◽  
Retinal Microvasculature

Optical coherence tomography angiography (OCT-A) was developed as an extension of OCT imaging. This technology allowed for the visualization of retinal microvasculature in vivo, without the need for contrast dye, provides depth-resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging. OCT-A has been recently used for noninvasive evaluation of macular and peripapillary capillary network alterations in diabetic retinopathy, and the ability to clearly visualize microvascular changes has allowed for a better assessment of the microvascular retinal alterations, retinal ischemia, and neovascularization in diabetic macular edema (DME) patient. The present paper aims to review the most recent information about the findings for diagnostic interpretation in DME using OCT angiography.

scholarly journals Evaluation of vessel density in disorganization of retinal inner layers after resolved diabetic macular edema using optical coherence tomography angiography

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244789
Author(s):  
Gilda Cennamo ◽  
Daniela Montorio ◽  
Federica Fossataro ◽  
Claudia Fossataro ◽  
Fausto Tranfa
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Negative Correlation ◽  
Optical Coherence Tomography Angiography ◽  
Significant Negative Correlation ◽  
Vessel Density ◽  
Optical Coherence ◽  
Capillary Plexus

Purpose To evaluate the retinal vessel density (VD) in the macular region and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with and without disorganization of retinal inner layers (DRILs) after resolution of diabetic macular edema. Methods Thirty-seven eyes of 37 DRIL patients (mean age 63 ± 13.97 years), 30 eyes of 30 no DRIL patients and 35 eyes of 35 controls were enrolled in this study. We evaluated the VD in the macular region of superficial capillary plexus (SCP), deep capillary plexus (DCP) and FAZ area. Results DRIL and no DRIL groups showed decreased VD in SCP and DCP (p<0.05) and a larger FAZ area (p<0.001) compared to controls. However, DRIL patients revealed a statistically significant reduction in VD of SCP (p = 0.041) and a greater FAZ area (p<0.001) with respect to no DRIL patients. We found a significant negative correlation between the VD of the foveal SCP (r = -0.414, p = 0.011), foveal DCP (r = -0.358, p = 0.025) and best corrected visual acuity (BCVA) in DRIL group. Moreover there was a significant positive correlation between the FAZ area (r = 0.425, p = 0.034) and BCVA. Therefore, in presence of DRILs lower VD values of SCP and DCP and a larger FAZ area correlated with a worse visual acuity. In no DRILs group, there was a significant negative correlation between the VD of the foveal DCP and BCVA. Conclusion OCTA highlights the role of retinal vascular ischemia in the pathogenesis of DRILs. This parameter could represent an important functional predictive factor in diabetic patients.

scholarly journals Optical Coherence Tomography Angiography of Macular Perfusion Changes after Anti-VEGF Therapy for Diabetic Macular Edema: A Systematic Review

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Ayman G. Elnahry ◽  
Gehad A. Elnahry
Keyword(s):  
Systematic Review ◽  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Density ◽  
Optical Coherence ◽  
Scanning Protocol ◽  
Anti Vegf ◽  
Retinal Microvasculature

Background. Diabetic macular edema (DME) is a major cause of vision loss in diabetics that is currently mainly treated by antivascular endothelial growth factor (VEGF) agents. The effect of these agents on macular perfusion (MP) is a current concern. Optical coherence tomography angiography (OCTA) is an imaging modality that allows noninvasive high-resolution retinal microvasculature imaging. Several recent studies evaluated the effect of anti-VEGF agents on the MP of DME patients using OCTA. Our aim is to provide a systematic review of these studies. Methods. Multiple databases were searched including PubMed, Ovid Medline, EMBASE, and Google Scholar for relevant studies published between January 2016 and November 2020 which were included in this review. Studies were compared regarding their design, the number of included patients, the machine and scanning protocol used, the inclusion and exclusion criteria, the number of injections given, the type of anti-VEGF agent used, the outcome measures assessed, and the effect of injections on different MP parameters. Results. A total of 16 studies were included. The studies assessed various OCTA parameters that define MP including the foveal avascular zone area and superficial and deep vascular density and yielded conflicting results. Seven studies showed stable or improved MP following treatment, while 7 studies showed worsening MP following treatment, and 2 studies showed inconclusive results. This could have been due to differences in study design, inclusion criteria, type of anti-VEGF agents used, treatment duration, and methods of image analysis and vascular density quantification. All identified studies were noncomparative case series, and 14 of them (87.5%) used the RTVue XR Avanti OCTA machine. Only one study compared OCTA to fluorescein angiography findings. Conclusion. Analysis of MP changes following VEGF inhibition for DME could benefit from a unified scanning protocol and analysis approach that uses similar study designs to eliminate potential sources of bias. This may provide more definitive conclusions regarding the effect of treatment on MP.

scholarly journals ASSOCIATION OF THE EXTENT OF DIABETIC MACULAR EDEMA AS ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY WITH VISUAL ACUITY AND RETINAL OUTCOME VARIABLES

Retina ◽  
2009 ◽  
Vol 29 (3) ◽  
pp. 300-305 ◽  
Author(s):  
DAVID J. BROWNING ◽  
RAJENDRA S. APTE ◽  
SUSAN B. BRESSLER ◽  
KAKARLA V. CHALAM ◽  
RONALD P. DANIS ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence

scholarly journals Multifocal electroretinogram in diabetic macular edema; Correlation with visual acuity and optical coherence tomography

2015 ◽  
Vol 10 (2) ◽  
pp. 165 ◽  
Author(s):  
Hamid Riazi-Esfahani ◽  
Ebrahim Jafarzadehpur ◽  
Ali Mirzajani ◽  
Hossein Talebi ◽  
Abdulrahim Amini ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Multifocal Electroretinogram ◽  
Optical Coherence

scholarly journals Stepwise segmentation error correction in optical coherence tomography angiography images of patients with diabetic macular edema

2020 ◽  
Vol 12 ◽  
pp. 251584142094793
Author(s):  
Khalil Ghasemi Falavarjani ◽  
Reza Mirshahi ◽  
Shahriar Ghasemizadeh ◽  
Mahsa Sardarinia
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence Tomography Angiography ◽  
Plexiform Layer ◽  
Vessel Density ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Density Measurements ◽  
Segmentation Error

Aim: To determine the minimum number of optical coherence tomography B-scan corrections required to provide acceptable vessel density measurements on optical coherence tomography angiography images in eyes with diabetic macular edema. Methods: In this prospective, noninterventional case series, the optical coherence tomography angiography images of eyes with center-involving diabetic macular edema were assessed. Optical coherence tomography angiography imaging was performed using RTVue Avanti spectral-domain optical coherence tomography system with the AngioVue software (V.2017.1.0.151; Optovue, Fremont, CA, USA). Segmentation error was recorded and manually corrected in the inner retinal layers in the central foveal, 100th and 200th optical coherence tomography B-scans. The segmentation error correction was then continued until all optical coherence tomography B-scans in whole en face image were corrected. At each step, the manual correction of each optical coherence tomography B-scan was propagated to whole image. The vessel density and retinal thickness were recorded at baseline and after each optical coherence tomography B-scan correction. Results: A total of 36 eyes of 26 patients were included. To achieve full segmentation error correction in whole en face image, an average of 1.72 ± 1.81 and 5.57 ± 3.87 B-scans was corrected in inner plexiform layer and outer plexiform layer, respectively. The change in the vessel density measurements after complete segmentation error correction was statistically significant after inner plexiform layer correction. However, no statistically significant change in vessel density was found after manual correction of the outer plexiform layer. The vessel density measurements were statistically significantly different after single central foveal B-scan correction of inner plexiform layer compared with the baseline measurements ( p = 0.03); however, it remained unchanged after further segmentation corrections of inner plexiform layer. Conclusion: Multiple optical coherence tomography B-scans should be manually corrected to address segmentation error in whole images of en face optical coherence tomography angiography in eyes with diabetic macular edema. Correction of central foveal B-scan provides the most significant change in vessel density measurements in eyes with diabetic macular edema.

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