scholarly journals Social defeat stress causes selective attenuation of neuronal activity in the ventromedial prefrontal cortex

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Reimi Abe ◽  
Sakura Okada ◽  
Ryota Nakayama ◽  
Yuji Ikegaya ◽  
Takuya Sasaki
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Social Defeat ◽  
Ventromedial Prefrontal Cortex ◽  
Social Defeat Stress

scholarly journals Dissociable roles of cortical excitation-inhibition balance during patch-leaving versus value-guided decisions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Luca F. Kaiser ◽  
Theo O. J. Gruendler ◽  
Oliver Speck ◽  
Lennart Luettgau ◽  
Gerhard Jocham
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Neuronal Activity ◽  
Ventromedial Prefrontal Cortex ◽  
Anterior Cingulate ◽  
Mutual Inhibition ◽  
Dorsal Anterior Cingulate Cortex ◽  
Cortical Excitation ◽  
The Cost

AbstractIn a dynamic world, it is essential to decide when to leave an exploited resource. Such patch-leaving decisions involve balancing the cost of moving against the gain expected from the alternative patch. This contrasts with value-guided decisions that typically involve maximizing reward by selecting the current best option. Patterns of neuronal activity pertaining to patch-leaving decisions have been reported in dorsal anterior cingulate cortex (dACC), whereas competition via mutual inhibition in ventromedial prefrontal cortex (vmPFC) is thought to underlie value-guided choice. Here, we show that the balance between cortical excitation and inhibition (E/I balance), measured by the ratio of GABA and glutamate concentrations, plays a dissociable role for the two kinds of decisions. Patch-leaving decision behaviour relates to E/I balance in dACC. In contrast, value-guided decision-making relates to E/I balance in vmPFC. These results support mechanistic accounts of value-guided choice and provide evidence for a role of dACC E/I balance in patch-leaving decisions.

scholarly journals Unique effects of social defeat stress in adolescent male mice on the Netrin-1/DCC pathway, prefrontal cortex dopamine and cognition (Social stress in adolescent vs. adult male mice)

eNeuro ◽  
2021 ◽  
pp. ENEURO.0045-21.2021
Author(s):  
Philip Vassilev ◽  
Andrea Haree Pantoja-Urban ◽  
Michel Giroux ◽  
Dominique Nouel ◽  
Giovanni Hernandez ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Adult Male ◽  
Social Stress ◽  
Social Defeat ◽  
Adolescent Male ◽  
Male Mice ◽  
Social Defeat Stress

scholarly journals Chronic Social Defeat Stress Modulates Dendritic Spines Structural Plasticity in Adult Mouse Frontal Association Cortex

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Yu Shu ◽  
Tonghui Xu
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Neural Circuits ◽  
Neural Circuit ◽  
Structural Plasticity ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
Stress Experience ◽  
Spine Dynamics

Chronic stress is associated with occurrence of many mental disorders. Previous studies have shown that dendrites and spines of pyramidal neurons of the prefrontal cortex undergo drastic reorganization following chronic stress experience. So the prefrontal cortex is believed to play a key role in response of neural system to chronic stress. However, how stress induces dynamic structural changes in neural circuit of prefrontal cortex remains unknown. In the present study, we examined the effects of chronic social defeat stress on dendritic spine structural plasticity in the mouse frontal association (FrA) cortexin vivousing two-photon microscopy. We found that chronic stress altered spine dynamics in FrA and increased the connectivity in FrA neural circuits. We also found that the changes in spine dynamics in FrA are correlated with the deficit of sucrose preference in defeated mice. Our findings suggest that chronic stress experience leads to adaptive change in neural circuits that may be important for encoding stress experience related memory and anhedonia.

scholarly journals Whole-brain mapping of neuronal activity in mice after social defeat stress

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-1-36
Author(s):  
Hisato Igarashi ◽  
Atsushi Kasai ◽  
Misaki Niu ◽  
Kaoru Seiriki ◽  
Takahiro Kuwaki ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Brain Mapping ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Whole Brain

scholarly journals (R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress

2019 ◽  
Vol 22 (10) ◽  
pp. 675-679 ◽  
Author(s):  
Jiancheng Zhang ◽  
Youge Qu ◽  
Lijia Chang ◽  
Yaoyu Pu ◽  
Kenji Hashimoto
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Single Injection ◽  
Social Defeat ◽  
Spine Density ◽  
Social Defeat Stress ◽  
Dendritic Spine Density ◽  
Antidepressant Effects ◽  
Chronic Social Defeat Stress ◽  
Medial Pfc

Abstract Background A recent study demonstrated that spine formation rates by ketamine in the prefrontal cortex (PFC) were not altered at 3–6 h following a single injection, but were markedly altered at 12–24 h. Here, we investigated the acute (3 h post-treatment) effects of (R)-ketamine in the decreased spine density in the medial PFC (mPFC) and hippocampus in susceptible mice after chronic social defeat stress (CSDS). Methods (R)-ketamine (10 mg/kg) or saline was administered intraperitoneally to CSDS-susceptible mice. Dendritic spine density in the mPFC and hippocampus was measured 3 h after a single injection. Results (R)-ketamine significantly ameliorated the decreased spine density in the prelimbic area of mPFC, Cornu Ammonis3, and dentate gyrus of the hippocampus of CSDS-susceptible mice Conclusions This study suggests that (R)-ketamine rapidly ameliorates the decreased spine density in the mPFC and hippocampus of CSDS-susceptible mice, resulting in its rapid-acting antidepressant effects.

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