scholarly journals Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ou Tan ◽  
David S. Greenfield ◽  
Brian A. Francis ◽  
Rohit Varma ◽  
Joel S. Schuman ◽  
...  
Keyword(s):  
Visual Field ◽  
Nerve Fiber ◽  
Weighted Averaging ◽  
Mean Deviation ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Maximal Correlation ◽  
Advanced Stages ◽  
Higher Sensitivity

AbstractTo construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. NFL_MD had significantly higher correlation (Pearson R: 0.68 vs 0.55, p < 0.001) with VF_MD than the overall NFL thickness. NFL_MD also had significantly higher sensitivity in detecting PPG (0.14 vs 0.08) and PG (0.60 vs 0.43) at the 99% specificity level. NFL_MD had better reproducibility than VF_MD (0.35 vs 0.69 dB, p < 0.001). The differences between NFL_MD and VF_MD were −0.34 ± 1.71 dB, −0.01 ± 2.08 dB and 3.54 ± 3.18 dB and 7.17 ± 2.68 dB for PPG, early PG, moderate PG, and severe PG subgroups, respectively. In summary, OCT-based NFL_MD has better correlation with VF_MD and greater diagnostic sensitivity than the average NFL thickness. It has better reproducibility than VF_MD, which may be advantageous in detecting progression. It agrees well with VF_MD in early glaucoma but underestimates damage in moderate~advanced stages.

Retinal Nerve Fiber Layer Normative Classification by Optical Coherence Tomography for Prediction of Future Visual Field Loss

2011 ◽  
Vol 52 (5) ◽  
pp. 2634 ◽  
Author(s):  
Kyung Rim Sung ◽  
Sophia Kim ◽  
Youngrok Lee ◽  
Sung-Cheol Yun ◽  
Jung Hwa Na
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Visual Field Loss ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

The Correlation Between Visual Field Defects and Focal Nerve Fiber Layer Thickness Measured With Optical Coherence Tomography in the Evaluation of Glaucoma

2009 ◽  
Vol 18 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Ilgaz Sagdic Yalvac ◽  
Muhsin Altunsoy ◽  
Semra Cansever ◽  
Banu Satana ◽  
Umit Eksioglu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Visual Field Defects ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Field Defects

scholarly journals Optical Coherence TomographyStudy of peripapillary Nerve Fiber layer ThicknessinThyroid Associated Ophthalmopathy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
Z I R Elkady ◽  
S Elwan ◽  
A M A Said ◽  
Y A T Farweez ◽  
M M M Mahdy
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Nerve Fiber ◽  
Severity Score ◽  
University Hospital ◽  
Visual Field Defects ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Severity Of The Disease

Abstract Background Thyroid Associated Ophthalmopathy (TAO) or Graves Opthalmopathy (GO) is a very common autoimmune disorder of the thyroid gland which activates the gland function and result in hyperthyroidism. Some patients with graves disease(GD) develop localized manifestations including GO and dermopathy. Dysthyroid optic neuropathy (DON) is impairment of optic nerve function due to GO, the most serious complication of GO which occurs in about 4–8% of patients, it occurs due to ischemia and inflammation of the optic nerve, also compression of the optic nerve due to enlargement of extraocular muscles at the apex of orbit. Objective To assess peripapillary retinal nerve fiber layer (pRNFL) thickness in GD and to correlate it with the severity of the disease. Patients and Methods This study was conducted on 40 eyes of 21 recently diagnosed GO patients (two patients were single eyed) recruited from Endocrinology clinic and examined at Ophthalmology clinic, Ain Shams University Hospital in the period from March 2018 to September 2018. Complete ophthalmologic examination, proptosis assessment of direction and degree, Visual Field (VF) examination, clinical activity score (CAS), severity score assessment and Optical Coherence Tomography (OCT) were performed to all patients . Results In the whole group of patients; the mean average pRNFL was 109.53 um ± 12.33 SD (range: 86 – 140), median MD was -4.53 (range:-0.66 to-18.95) and -8.04 ± -2.15 SD, mean PSD was 5.55 ± 3.8 SD (range: 1.11 to 12.73). Normal average pRNFL thickness (according to normative data base included in the OCT program) was found in 15 eyes (37.5%) and those had abnormal increase in thickness was 12 eyes (30%). Abnormal decrease in thickness was detected in 13 eyes (32.5%). Conclusion PRNFL thickness abnormalities were detected in 25 eyes (62%) of recently diagnosed GO patients. This might be associated with localized visual field defects. Regular follow up of intra ocular pressure (IOP), serial VF examinations, are required to decide further management of those patients, as OCT results were correlated with degree of eye protrusion and the severity of the disease (CAS and severity score).

scholarly journals Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma

2020 ◽  
Vol 212 ◽  
pp. 57-68
Author(s):  
Liang Liu ◽  
Ou Tan ◽  
Eliesa Ing ◽  
John C. Morrison ◽  
Beth Edmunds ◽  
...  
Keyword(s):  
Visual Field ◽  
Nerve Fiber ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Field Simulation ◽  
Tomographic Angiography

scholarly journals Peripapillary retinal nerve fiber layer thickness in different glaucoma stages measured by optical coherence tomography

2017 ◽  
Vol 74 (2) ◽  
pp. 121-126
Author(s):  
Maja Zivkovic ◽  
Vesna Jaksic ◽  
Predrag Jovanovic ◽  
Marko Zlatanovic ◽  
Gordana Zlatanovic ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Glaucomatous Damage ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Sd Oct

Background/Aim. One of the most reliable methods for structural measurements of glaucomatous damage is spectral domain optical coherence tomography (SD-OCT). The aim of this study was to measure peripapillary retinal nerve fiber layer (RNFL) thickness with SD-OCT in eyes with different stages of glaucoma, as well as to determine which sector in the peripapillary circle is the most vulnerable to glaucomatous damage. Methods. The study included 153 eyes of 93 patients with confirmed primary open angle glaucoma (POAG). All the patients underwent a complete ophthalmic examination, including visual field testing and peripapillary RNFL thickness measured by SD-OCT. They were divided into three subgroups: early, moderate and severe stage of glaucoma based on the mean deviation (MD) index of visual field. The results were presented as mean RNFL thickness: total, in the four quadrants and 12 clock-hour RNFL thickness. Results. The overall mean peripapillary RNFL was 74.95 ? 14.51 ?m. The lower quadrant had the thickest RNFL (92.78 ? 25.84 ?m), followed by upper (88.82 ? 22.04 ?m), nasal (64.31 ? 11.67 ?m) and temporal ones (54.02 ? 12.76 ?m), showing a significant difference (?2 = 273.36, DF = 3, p < 0.001). Comparison between RNFL thickness in early glaucoma and moderate and severe stages revealed that the most sensitive sectors were inferior and superior ones, as well as sectors at 5?7 clock hour position. The greatest decrease in RNFL thickness was observed in the 9 o'clock hour sector in all three glaucoma subgroups (46.99 ? 13.28 ?m), while the RNFL was the thickest in the 6 o'clock hour sector (102.63 ? 34.12 ?m). Conclusion. Peripapillary RNFL thickness is inversely proportional to the degree of glaucomatous damage: the greater the damage, the thinner peripapillary RNFL.

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