scholarly journals Endoscopic injection sclerotherapy improves liver function compared with endoscopic variceal ligation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tsuguru Hayashi ◽  
Tatsuyuki Watanabe ◽  
Michihiko Shibata ◽  
Shinsuke Kumei ◽  
Shinji Oe ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Confidence Interval ◽  
Linear Regression Analysis ◽  
Meld Score ◽  
Injection Sclerotherapy ◽  
Endoscopic Variceal Ligation ◽  
Endoscopic Injection Sclerotherapy ◽  
Endoscopic Injection ◽  
Liver Functions

AbstractLiver function is a most important prognostic factor in patients with liver cirrhosis. Also, portal hypertension is a fatal complication of liver cirrhosis and variceal treatment is indispensable. However, changes of liver functions after endoscopic variceal treatments are unknown. The aim of this study was to evaluate prognosis and liver functions after endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL). A total of liver cirrhotic 103 patients who underwent prophylactic EIS and EVL were enrolled. Overall survival rate was higher in EIS group than EVL group (p = 0.03). Multivariate analysis showed that EIS was a negative factor for death (HR: 0.46, 95% confidence interval: 0.24–0.88, p = 0.02). Liver functions were assessed by blood test taken at before and 3 months after treatment. In EIS group, albumin and prothrombin time improved (p < 0.01), leading to improvement of Child–Pugh score, ALBI score and MELD score (p < 0.05). However, these did not improve in EVL group. EIS was a significant factor related to the elevated value of albumin after treatment in linear regression analysis (estimated regression coefficient: 0.17, 95% confidence interval: 0.05–0.29, p = 0.005). These results revealed that EIS could improve liver functions and prognosis.

scholarly journals Endoscopic Injection Sclerotherapy Improves Liver Function Compared with Endoscopic Variceal Ligation

2021 ◽  
Author(s):  
Tsuguru Hayashi ◽  
Tatsuyuki Watanabe ◽  
Michihiko Shibata ◽  
Shinsuke Kumei ◽  
Shinji Oe ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Blood Test ◽  
Meld Score ◽  
Injection Sclerotherapy ◽  
Endoscopic Variceal Ligation ◽  
Endoscopic Injection Sclerotherapy ◽  
Fatal Complication ◽  
Endoscopic Injection ◽  
Liver Functions

Abstract Liver function is a most important prognostic factor in patients with liver cirrhosis. Also, portal hypertension is a fatal complication of liver cirrhosis and variceal treatment is indispensable. However, changes of liver functions after endoscopic variceal treatments are still unknown. The aim of this study was to evaluate liver functions after endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL). A total of liver cirrhotic 103 patients who underwent prophylactic EIS and EVL were enrolled. Liver functions were assessed by blood test taken at before and 3 months after EIS and EVL. In EIS group, albumin and prothrombin time improved significantly (p < 0.01), which led to improvement of Child-Pugh score, ALBI score and MELD score (p < 0.05). However, these factors did not improve in EVL group. Overall survival (OS) rate was significantly higher in EIS group than EVL group. Subsequently, in EIS group patients who improved albumin showed significantly better OS than those who did not improved. In multivariate analysis, improvement of albumin at 3 months after EIS was associated with better prognosis (HR: 0.38, 95% confidence interval: 0.19- 0.77, p = 0.007). These results revealed that EIS could improve liver functions and prognosis.

Development of the Cruveilhier-Baumgarten Syndrome after Endoscopic Obliteration of Oesophageal Varices

1989 ◽  
Vol 30 (4) ◽  
pp. 401-402 ◽  
Author(s):  
J. B. Dilawari ◽  
Y. K. Chawla ◽  
U. Kaur
Keyword(s):  
Liver Cirrhosis ◽  
Injection Sclerotherapy ◽  
Oesophageal Varices ◽  
Endoscopic Injection Sclerotherapy ◽  
Endoscopic Injection

A patient with post-necrotic liver cirrhosis, presenting with recurrent haematemesis and melena due to oesophageal varices, received repeated endoscopic injection sclerotherapy. The Cruveilhier-Baumgarten syndrome developed 11 months after variceal obliteration. Neither rebleeding nor recurrence of varices was observed during a follow up period of 12 months after obliteration of varices.

scholarly journals Endoscopic therapy for gastro-oesophageal varices of Caroli’s syndrome: a case report

2019 ◽  
Vol 48 (2) ◽  
pp. 030006051987799 ◽  
Author(s):  
Song Wang ◽  
Mei Xiao ◽  
Liqun Hua ◽  
Yong Jia ◽  
Si Chen ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Hepatic Fibrosis ◽  
Endoscopic Therapy ◽  
Tissue Adhesive ◽  
Injection Sclerotherapy ◽  
Oesophageal Varices ◽  
Endoscopic Injection Sclerotherapy ◽  
Endoscopic Injection ◽  
Caroli’S Syndrome

Caroli’s disease (CD) is a very rare congenital disorder that is characterized by non-obstructive, segmental and cystic dilatation of intrahepatic ducts. Most patients with CD are asymptomatic, but some patients may suffer from hepatic fibrosis, liver cirrhosis or/and portal hypertension. In complex CD, cystic dilatations of the intrahepatic bile ducts can be present with congenital hepatic fibrosis, liver cirrhosis, portal hypertension, oesophageal varices and autosomal recessive polycystic kidney disease; a condition known as Caroli’s syndrome. This report describes the case of a 28-year-old woman that had gastro-oesophageal varices that were caused by hepatic fibrosis and portal hypertension as part of Caroli’s syndrome. The patient underwent successful treatment with endoscopic injection sclerotherapy with lauromacrogol and endoscopic variceal obturation using tissue adhesive. There were no immediate complications and the patient remained free of complications at 1-year follow-up. There are no current reports in the published literature describing Caroli’s syndrome induced by gastro-oesophageal varices that were treated by a combination of endoscopic injection sclerotherapy and endoscopic variceal obturation. Endoscopic therapy was an effective technique for the treatment of gastro-oesophageal varices in a patient with Caroli’s syndrome awaiting a liver transplant.

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