scholarly journals Intraobserver and interobserver reliability of the R/D score for evaluation of iris configuration by ultrasound biomicroscopy, in patients with pigment dispersion syndrome

Eye ◽  
2002 ◽  
Vol 16 (6) ◽  
pp. 722-726 ◽  
Author(s):  
M O Balidis ◽  
C Bunce ◽  
K Boboridis ◽  
J Salzman ◽  
R P L Wormald ◽  
...  
Keyword(s):  
Interobserver Reliability ◽  
Ultrasound Biomicroscopy ◽  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome

Ultrasound Biomicroscopy in Pigment Dispersion Syndrome

Ophthalmology ◽  
1994 ◽  
Vol 101 (2) ◽  
pp. 332-339 ◽  
Author(s):  
Seth D. Potash ◽  
Celso Tello ◽  
Jeffrey Liebmann ◽  
Robert Ritch
Keyword(s):  
Ultrasound Biomicroscopy ◽  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome

scholarly journals Implantation of a trifocal toric intraocular lens to a patient with pigment dispersion syndrome

2019 ◽  
Vol 100 (3) ◽  
pp. 495-499
Author(s):  
R F Akhmetshin ◽  
M R Gilyazev ◽  
A T Galeeva ◽  
S N Bulgar
Keyword(s):  
Intraocular Pressure ◽  
Intraocular Lens ◽  
Anterior Segment ◽  
Ultrasound Biomicroscopy ◽  
Pigment Dispersion ◽  
Toric Intraocular Lens ◽  
Lens Extraction ◽  
Pigment Dispersion Syndrome ◽  
Myopic Astigmatism ◽  
Peripheral Iridotomy

Aim. To present a clinical case of treatment of pigment dispersion syndrome by clear lens extraction and implantation of a toric intraocular lens in a patient with myopic astigmatism. Methods. A 33-year-old patient with a diagnosis of moderate myopia, complex mild myopic astigmatism, pigment dispersion syndrome of both eyes. Results. The first stage was laser peripheral iridotomy of both eyes. On follow-up pathological irido-zonular contact and increases intraocular pressure by 2 mm persisted. The second stage included clear lens extraction and implantation of a toric multifocal intraocular lens to both eyes. In 2 months, distance and near visual acuity was 1.0, intraocular pressure was normal, no pathological irido-zonular contact was observed according to the ultrasound biomicroscopy. Conclusion. Implantation of an intraocular lens in patients with myopia and pigment dispersion syndrome is both a method of preventing pigment glaucoma and myopia correction; patients with pigment dispersion syndrome after peripheral iridotomy should monitor the state of the anterior segment of the eye and the effectiveness of the treatment by ultrasound biomicroscopy.

Ultrasound Biomicroscopy in Pigment Dispersion Syndrome

Ophthalmology ◽  
1994 ◽  
Vol 101 (9) ◽  
pp. 1475-1476 ◽  
Author(s):  
Charles J. Pavlin
Keyword(s):  
Ultrasound Biomicroscopy ◽  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome

scholarly journals Iris configuration in accommodation in pigment dispersion syndrome

Eye ◽  
2002 ◽  
Vol 16 (6) ◽  
pp. 694-700 ◽  
Author(s):  
M O Balidis ◽  
C Bunce ◽  
C J Sandy ◽  
R P L Wormald ◽  
M H Miller
Keyword(s):  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome

scholarly journals Exome-based investigation of the genetic basis of human pigmentary glaucoma

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Carly van der Heide ◽  
Wes Goar ◽  
Kacie J. Meyer ◽  
Wallace L. M. Alward ◽  
Erin A. Boese ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Immunohistochemical Analysis ◽  
Pigment Dispersion ◽  
Pigmentary Glaucoma ◽  
Visual Disability ◽  
Primary Analysis ◽  
Human Donor ◽  
Similar Frequency ◽  
Pigment Dispersion Syndrome ◽  
Rare Mutations

Abstract Background Glaucoma is a leading cause of visual disability and blindness. Release of iris pigment within the eye, pigment dispersion syndrome (PDS), can lead to one type of glaucoma known as pigmentary glaucoma. PDS has a genetic component, however, the genes involved with this condition are largely unknown. We sought to discover genes that cause PDS by testing cohorts of patients and controls for mutations using a tiered analysis of exome data. Results Our primary analysis evaluated melanosome-related genes that cause dispersion of iris pigment in mice (TYRP1, GPNMB, LYST, DCT, and MITF). We identified rare mutations, but they were not statistically enriched in PDS patients. Our secondary analyses examined PMEL (previously linked with PDS), MRAP, and 19 other genes. Four MRAP mutations were identified in PDS cases but not in controls (p = 0.016). Immunohistochemical analysis of human donor eyes revealed abundant MRAP protein in the iris, the source of pigment in PDS. However, analysis of MRAP in additional cohorts (415 cases and 1645 controls) did not support an association with PDS. We also did not confirm a link between PMEL and PDS in our cohorts due to lack of reported mutations and similar frequency of the variants in PDS patients as in control subjects. Conclusions We did not detect a statistical enrichment of mutations in melanosome-related genes in human PDS patients and we found conflicting data about the likely pathogenicity of MRAP mutations. PDS may have a complex genetic basis that is not easily unraveled with exome analyses.

Pigment dispersion syndrome (PDS) assessment by dynamic light scattering

2003 ◽  
Author(s):  
Luca Pollonini ◽  
Andrea Pasquali ◽  
Luigi Rovati ◽  
Rafat R. Ansari ◽  
Alessandra Franzoni ◽  
...  
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome

Pigment dispersion syndrome and its implications for glaucoma

2021 ◽  
Author(s):  
Andres Bustamante-Arias ◽  
Raul E. Ruiz-Lozano ◽  
J. Carlos Alvarez-Guzman ◽  
Sara Gonzalez-Godinez ◽  
Alejandro Rodriguez-Garcia
Keyword(s):  
Pigment Dispersion ◽  
Pigment Dispersion Syndrome
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