scholarly journals Characteristics of Long Non-coding RNAs in the Brown Norway Rat and Alterations in the Dahl Salt-Sensitive Rat

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Feng Wang ◽  
Liping Li ◽  
Haiming Xu ◽  
Yong Liu ◽  
Chun Yang ◽  
...  
Keyword(s):  
Brown Norway ◽  
Norway Rat ◽  
Brown Norway Rat ◽  
Non Coding Rnas

Brown Norway Rat Asthma Model of Diphenylmethane 4,4′-Diisocyanate

2005 ◽  
Vol 17 (13) ◽  
pp. 729-739 ◽  
Author(s):  
Jürgen Pauluhn
Keyword(s):  
Brown Norway ◽  
Norway Rat ◽  
Asthma Model ◽  
Brown Norway Rat

scholarly journals Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries

2017 ◽  
Vol 312 (6) ◽  
pp. F971-F981 ◽  
Author(s):  
Fan Fan ◽  
Mallikarjuna R. Pabbidi ◽  
Ying Ge ◽  
Longyang Li ◽  
Shaoxun Wang ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Vascular Dysfunction ◽  
Cerebral Arteries ◽  
Chromosome 1 ◽  
Brown Norway ◽  
Myogenic Response ◽  
Norway Rat ◽  
Vasoconstrictor Response ◽  
Brown Norway Rat ◽  
Interfering Rna

We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA). Control Af-arts constricted by 10 ± 1% in response to an elevation in pressure from 60 to 120 mmHg but dilated by 4 ± 3% when treated with Add3 DsiRNA. Add3 DsiRNA had no effect on the vasoconstrictor response of the Af-art to norepinephrine (10−7 M). Add3 DsiRNA had a similar effect on the attenuation of the myogenic response in the MCA. Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. This is the first study demonstrating that Add3 plays a role in the regulation of potassium channel function and vascular reactivity. It supports the hypothesis that sequence variants in Add3, which we previously identified in FHH rats, may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation.

scholarly journals 1436: Bosentan, an Endothelin Dual Receptor Antagonist, Potentiates Nitric Oxide-Mediated Erectile Response in an Aging Brown-Norway Rat Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 378-378
Author(s):  
Steven White ◽  
Michael Albo ◽  
Mahadevan Rajasekaran
Keyword(s):  
Nitric Oxide ◽  
Receptor Antagonist ◽  
Rat Model ◽  
Brown Norway ◽  
Norway Rat ◽  
Brown Norway Rat ◽  
Erectile Response

Vasopressin and oxytocin excretion in the Brown-Norway rat in relation to aging, water metabolism and testosterone

1988 ◽  
Vol 44 (3) ◽  
pp. 241-252 ◽  
Author(s):  
Elmer Goudsmit ◽  
Eric Fliers ◽  
Dick F. Swaab
Keyword(s):  
Brown Norway ◽  
Water Metabolism ◽  
Norway Rat ◽  
Brown Norway Rat

Brief Communication : High Incidence of Spontaneous Urinary Bladder and Ureter Tumors in the Brown Norway Rat

1974 ◽  
Vol 52 (3) ◽  
pp. 1005-1008 ◽  
Author(s):  
Gary A. Boorman ◽  
Carel F. Hollander
Keyword(s):  
Urinary Bladder ◽  
Brown Norway ◽  
Norway Rat ◽  
High Incidence ◽  
Brown Norway Rat

Role Of Nitric Oxide And Arginase On Muscarinic-induced Contractility In Isolated Trachea Of Non-challenged And Allergen-challenged Brown Norway Rat

2010 ◽  
Author(s):  
Michel R. Corboz ◽  
Maria A. Rivelli ◽  
Jonathan E. Phillips ◽  
Richard W. Chapman ◽  
John Anthes
Keyword(s):  
Nitric Oxide ◽  
Brown Norway ◽  
Norway Rat ◽  
Isolated Trachea ◽  
Brown Norway Rat

scholarly journals Age-Related Histological Changes in Kidneys of Brown Norway Rat

2014 ◽  
Vol 76 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Akira YABUKI ◽  
Shinichiro YONESHIGE ◽  
Shin TANAKA ◽  
Masashi TSUJIO ◽  
Sawane MITANI ◽  
...  
Keyword(s):  
Brown Norway ◽  
Histological Changes ◽  
Norway Rat ◽  
Age Related ◽  
Brown Norway Rat

Outer- and Middle-Ear Contributions to Presbycusis in the Brown Norway Rat

2007 ◽  
Vol 13 (1) ◽  
pp. 37-52 ◽  
Author(s):  
Michael Anne Gratton ◽  
Kristin Bateman ◽  
Joseph F. Cannuscio ◽  
James C. Saunders
Keyword(s):  
Middle Ear ◽  
Brown Norway ◽  
Norway Rat ◽  
Brown Norway Rat
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