From the first ambitious imagination of tropinone biosynthesis mechanism in plants published in 1917 to the de novo production of scopolamine in yeast realized in 2020, what did we learn from this long story of more than 100 years old?
This article comprehensively reviews basidiomycete enzymes and their genes involved in natural product biosynthesis and primarily focuses on typical pathways and enzymes, along with the methods applied to investigate mushroom metabolism.